ExplorEnz: EC 1.14.13.252

Your query returned 1 entry. Printable version

1.14.13.252

Accepted name:

putrescine N-hydroxylase

Reaction:

putrescine + NADPH + H⁺ + O₂ = N-hydroxyputrescine + NADP⁺ + H₂O

For diagram of putrebactin biosynthesis, click here

Other name(s):

alcA (gene name); pubA (gene name); fbsI (gene name)

Systematic name:

putrescine,NADPH:oxygen oxidoreductase (N-hydroxylating)

Comments:

Contains FAD. The enzyme, characterized from multiple bacterial species, participates in the biosynthesis of assorted siderophores.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Kadi, N., Arbache, S., Song, L., Oves-Costales, D. and Challis, G.L. Identification of a gene cluster that directs putrebactin biosynthesis in Shewanella species: PubC catalyzes cyclodimerization of N-hydroxy-N-succinylputrescine. J. Am. Chem. Soc. 130 (2008) 10458–10459. [DOI] [PMID: 18630910]
2.	Li, B., Lowe-Power, T., Kurihara, S., Gonzales, S., Naidoo, J., MacMillan, J.B., Allen, C. and Michael, A.J. Functional identification of putrescine C- and N-hydroxylases. ACS Chem. Biol. 11 (2016) 2782–2789. [DOI] [PMID: 27541336]
3.	Lyons, N.S., Bogner, A.N., Tanner, J.J. and Sobrado, P. Kinetic and structural characterization of a flavin-dependent putrescine N-hydroxylase from Acinetobacter baumannii. Biochemistry 61 (2022) 2607–2620. [DOI] [PMID: 36314559]

[EC 1.14.13.252 created 2024]