|
Your query returned 1 entry. Printable version
EC | 1.14.13.232 | ||||
Accepted name: | 6-methylpretetramide 4-monooxygenase | ||||
Reaction: | 6-methylpretetramide + NADPH + H+ + O2 = 4-hydroxy-6-methylpretetramide + NADP+ + H2O | ||||
For diagram of tetracycline biosynthesis, click here | |||||
Glossary: | 6-methylpretetramide = 1,3,10,11,12-pentahydroxy-6-methyltetracene-2-carboxamide 4-hydroxy-6-methylpretetramide = 1,3,4,10,11,12-hexahydroxy-6-methyltetracene-2-carboxamide |
||||
Systematic name: | 6-methylpretetramide,NADPH:oxygen oxidoreductase (4-hydroxylating) | ||||
Comments: | The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. That bacterium possesses two enzymes that can catalyse the reaction - OxyE is the main isozyme, while OxyL has a lower activity. OxyL is bifunctional, and its main function is EC 1.14.13.233, 4-hydroxy-6-methylpretetramide 12a-monooxygenase. Contains FAD. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
| ||||