| EC |
1.14.13.216 |
| Accepted name: |
asperlicin C monooxygenase |
| Reaction: |
asperlicin C + NAD(P)H + H+ + O2 = asperlicin E + NAD(P)+ + H2O |
| Other name(s): |
AspB |
| Systematic name: |
asperlicin C,NAD(P)H:oxygen oxidoreductase |
| Comments: |
The enzyme, characterized from the fungus Aspergillus alliaceus, contains an FAD cofactor. The enzyme inserts a hydroxyl group, leading to formation of a N-C bond that creates an additional cycle between the bicyclic indole and the tetracyclic core moieties, resulting in the heptacyclic asperlicin E. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Haynes, S.W., Gao, X., Tang, Y. and Walsh, C.T. Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. J. Am. Chem. Soc. 134 (2012) 17444–17447. [DOI] [PMID: 23030663] |
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| [EC 1.14.13.216 created 2016] |
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