The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: benzoyl-CoA 2,3-epoxidase
Reaction: benzoyl-CoA + NADPH + H+ + O2 = 2,3-epoxy-2,3-dihydrobenzoyl-CoA + NADP+ + H2O
For diagram of Benzoyl-CoA catabolism, click here
Other name(s): benzoyl-CoA dioxygenase/reductase (incorrect); BoxBA; BoxA/BoxB system; benzoyl-CoA 2,3-dioxygenase (incorrect)
Systematic name: benzoyl-CoA,NADPH:oxygen oxidoreductase (2,3-epoxydizing)
Comments: The enzyme is involved in aerobic benzoate metabolism in Azoarcus evansii. BoxB functions as the oxygenase part of benzoyl-CoA oxygenase in conjunction with BoxA, the reductase component, which upon binding of benzoyl-CoA, transfers two electrons to the ring in the course of monooxygenation. BoxA is a homodimeric 46 kDa iron-sulfur-flavoprotein (FAD), BoxB is a monomeric iron-protein [1].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Zaar, A., Gescher, J., Eisenreich, W., Bacher, A. and Fuchs, G. New enzymes involved in aerobic benzoate metabolism in Azoarcus evansii. Mol. Microbiol. 54 (2004) 223–238. [DOI] [PMID: 15458418]
2.  Gescher, J., Zaar, A., Mohamed, M., Schagger, H. and Fuchs, G. Genes coding for a new pathway of aerobic benzoate metabolism in Azoarcus evansii. J. Bacteriol. 184 (2002) 6301–6315. [DOI] [PMID: 12399500]
3.  Mohamed, M.E., Zaar, A., Ebenau-Jehle, C. and Fuchs, G. Reinvestigation of a new type of aerobic benzoate metabolism in the proteobacterium Azoarcus evansii. J. Bacteriol. 183 (2001) 1899–1908. [DOI] [PMID: 11222587]
4.  Rather, L.J., Knapp, B., Haehnel, W. and Fuchs, G. Coenzyme A-dependent aerobic metabolism of benzoate via epoxide formation. J. Biol. Chem. 285 (2010) 20615–20624. [DOI] [PMID: 20452977]
[EC created 2010 as EC, transferred 2015 to EC]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald