ExplorEnz: EC 1.14.13.182

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1.14.13.182

Accepted name:

2-heptyl-3-hydroxy-4(1H)-quinolone synthase

Reaction:

2-heptyl-4(1H)-quinolone + NADH + H⁺ + O₂ = 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD⁺ + H₂O

Glossary:

2-heptyl-4(1H)-quinolone = 2-heptyl-4-hydroxyquinoline
2-heptyl-3-hydroxy-4(1H)-quinolone = 2-heptyl-3,4-dihydroxyquinoline

Other name(s):

PqsH; 2-heptyl-3,4-dihydroxyquinoline synthase

Systematic name:

2-heptyl-4(1H)-quinolone,NADH:oxygen oxidoreductase (3-hydroxylating)

Comments:

The enzyme from the bacterium Pseudomonas aeruginosa catalyses the terminal step in biosynthesis of the signal molecule 2-heptyl-3,4-dihydroxyquinoline that plays a role in regulation of virulence genes.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Schertzer, J.W., Brown, S.A. and Whiteley, M. Oxygen levels rapidly modulate Pseudomonas aeruginosa social behaviours via substrate limitation of PqsH. Mol. Microbiol. 77 (2010) 1527–1538. [DOI] [PMID: 20662781]

[EC 1.14.13.182 created 2013]