EC |
1.14.13.18 |
Accepted name: |
4-hydroxyphenylacetate 1-monooxygenase |
Reaction: |
4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = homogentisate + NAD(P)+ + H2O |
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For diagram of the homogentisate pathways, click here |
Other name(s): |
4-hydroxyphenylacetate 1-hydroxylase; 4-hydroxyphenylacetic 1-hydroxylase; 4-HPA 1-hydroxylase |
Systematic name: |
4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating) |
Comments: |
A flavoprotein (FAD). Also acts on 4-hydroxyhydratropate (forming 2-methylhomogentisate) and on 4-hydroxyphenoxyacetate (forming hydroquinone and glycolate). |
Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 55326-44-8 |
References: |
1. |
Hareland, W.A., Crawford, R.L., Chapman, P.J. and Dagley, S. Metabolic function and properties of 4-hydroxyphenylacetic acid 1-hydroxylase from Pseudomonas acidovorans. J. Bacteriol. 121 (1975) 272–285. [PMID: 234937] |
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[EC 1.14.13.18 created 1976] |
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