The Enzyme Database

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Accepted name: peptidyl-lysine (3S)-dioxygenase
Reaction: a [protein]-L-lysine + 2-oxoglutarate + O2 = a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
Other name(s): JMJD7 (gene name); Jumonji domain-containing protein 7; JmjC domain-containing protein 7
Systematic name: [protein]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3S-hydroxylating)
Comments: Requires iron(II). The enzyme acts on specific lysine residues in its substrates, and is stereo-specific. The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Markolovic, S., Zhuang, Q., Wilkins, S.E., Eaton, C.D., Abboud, M.I., Katz, M.J., McNeil, H.E., Lesniak, R.K., Hall, C., Struwe, W.B., Konietzny, R., Davis, S., Yang, M., Ge, W., Benesch, J.LP., Kessler, B.M., Ratcliffe, P.J., Cockman, M.E., Fischer, R., Wappner, P., Chowdhury, R., Coleman, M.L. and Schofield, C.J. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nat. Chem. Biol. 14 (2018) 688–695. [PMID: 29915238]
[EC created 2019]

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