ExplorEnz: EC 1.14.11.40

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1.14.11.40

Accepted name:

enduracididine β-hydroxylase

Reaction:

L-enduracididine + 2-oxoglutarate + O₂ = (3S)-3-hydroxy-L-enduracididine + succinate + CO₂

Glossary:

L-enduracididine = 3-[(4R)-2-iminoimidazolidin-4-yl]-L-alanine = 2-amino-3-[(2S)-iminoimidazolin-4-yl]propanoic acid
(3S)-3-hydroxy-L-enduracididine = (2S,3R)-2-amino-3-hydroxy-3-[(S)-2-iminoimidazolidin-4-yl]propanoic acid = (3R)-3-[(4S)-2-iminoimidazolidin-4-yl]-L-serine

Other name(s):

MppO; L-enduracididine,2-oxoglutarate:O₂ oxidoreductase (3-hydroxylating)

Systematic name:

L-enduracididine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Comments:

Fe²⁺-dependent enzyme. The enzyme is involved in biosynthesis of the nonproteinogenic amino acid β-hydroxyenduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotic), produced by Streptomyces hygroscopicus NRRL 30439.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Haltli, B., Tan, Y., Magarvey, N.A., Wagenaar, M., Yin, X., Greenstein, M., Hucul, J.A. and Zabriskie, T.M. Investigating β-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins. Chem. Biol. 12 (2005) 1163–1168. [DOI] [PMID: 16298295]
2.	Magarvey, N.A., Haltli, B., He, M., Greenstein, M. and Hucul, J.A. Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens. Antimicrob. Agents Chemother. 50 (2006) 2167–2177. [DOI] [PMID: 16723579]

[EC 1.14.11.40 created 2013]