The Enzyme Database

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Accepted name: deoxynogalonate monooxygenase
Reaction: deoxynogalonate + O2 = nogalonate + H2O
For diagram of nogalamycin biosynthesis, click here
Glossary: deoxynogalonate = [4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate
nogalonate = [4,5-dihydroxy-9,10-dioxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate
Other name(s): SnoaB (gene name); 12-deoxynogalonic acid oxidoreductase; [4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate oxidase; [4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate monooxygenase; deoxynogalonate oxidoreductase
Systematic name: deoxynogalonate:oxygen oxidoreductase
Comments: The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Koskiniemi, H., Grocholski, T., Schneider, G. and Niemi, J. Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (2009) 256–259. [DOI] [PMID: 19255477]
2.  Grocholski, T., Koskiniemi, H., Lindqvist, Y., Mantsala, P., Niemi, J. and Schneider, G. Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism. Biochemistry 49 (2010) 934–944. [DOI] [PMID: 20052967]
[EC created 2015]

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