| EC |
1.13.11.71 |
| Accepted name: |
carotenoid-9′,10′-cleaving dioxygenase |
| Reaction: |
all-trans-β-carotene + O2 = all-trans-10′-apo-β-carotenal + β-ionone |
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For diagram of 10′-apo-β-carotenal biosynthesis, click here |
| Other name(s): |
BCO2 (gene name); β-carotene 9′,10′-monooxygenase (misleading); all-trans-β-carotene:O2 oxidoreductase (9′,10′-cleaving) |
| Systematic name: |
all-trans-β-carotene:oxygen oxidoreductase (9′,10′-cleaving) |
| Comments: |
Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Kiefer, C., Hessel, S., Lampert, J.M., Vogt, K., Lederer, M.O., Breithaupt, D.E. and von Lintig, J. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J. Biol. Chem. 276 (2001) 14110–14116. [DOI] [PMID: 11278918] |
| 2. |
Lindqvist, A., He, Y.G. and Andersson, S. Cell type-specific expression of β-carotene 9′,10′-monooxygenase in human tissues. J. Histochem. Cytochem. 53 (2005) 1403–1412. [DOI] [PMID: 15983114] |
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| [EC 1.13.11.71 created 2012] |
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