| EC |
1.13.11.50 |
| Accepted name: |
acetylacetone-cleaving enzyme |
| Reaction: |
pentane-2,4-dione + O2 = acetate + 2-oxopropanal |
| Glossary: |
2-oxopropanal = methylglyoxal
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| Other name(s): |
Dke1; acetylacetone dioxygenase; diketone cleaving dioxygenase; diketone cleaving enzyme |
| Systematic name: |
acetylacetone:oxygen oxidoreductase |
| Comments: |
An iron(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 524047-53-8 |
| References: |
| 1. |
Straganz, G.D., Glieder, A., Brecker, L., Ribbons, D.W. and Steiner, W. Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii. Biochem. J. 369 (2003) 573–581. [DOI] [PMID: 12379146] |
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| [EC 1.13.11.50 created 2003] |
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