| EC |
1.1.99.6 |
| Accepted name: |
D-lactate dehydrogenase (acceptor) |
| Reaction: |
(R)-lactate + acceptor = pyruvate + reduced acceptor |
| Other name(s): |
D-2-hydroxy acid dehydrogenase; D-2-hydroxy-acid dehydrogenase; (R)-2-hydroxy-acid:acceptor 2-oxidoreductase |
| Systematic name: |
(R)-lactate:acceptor 2-oxidoreductase |
| Comments: |
The zinc flavoprotein (FAD) from the archaeon Archaeoglobus fulgidus cannot utilize NAD+, cytochrome c, methylene blue or dimethylnaphthoquinone as acceptors. In vitro it is active with artificial electron acceptors such as 2,6-dichlorophenolindophenol, but the physiological acceptor is not yet known. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 9028-83-5 |
| References: |
| 1. |
Reed, D.W. and Hartzell, P.L. The Archaeoglobus fulgidus D-lactate dehydrogenase is a Zn2+ flavoprotein. J. Bacteriol. 181 (1999) 7580–7587. [PMID: 10601217] |
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| [EC 1.1.99.6 created 1965, modified 2013] |
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