| EC |
1.1.99.39 |
| Accepted name: |
D-2-hydroxyglutarate dehydrogenase |
| Reaction: |
(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor |
| Other name(s): |
D2HGDH (gene name) |
| Systematic name: |
(R)-2-hydroxyglutarate:acceptor 2-oxidoreductase |
| Comments: |
Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Engqvist, M., Drincovich, M.F., Flugge, U.I. and Maurino, V.G. Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and β-oxidation pathways. J. Biol. Chem. 284 (2009) 25026–25037. [DOI] [PMID: 19586914] |
| 2. |
Achouri, Y., Noel, G., Vertommen, D., Rider, M.H., Veiga-Da-Cunha, M. and Van Schaftingen, E. Identification of a dehydrogenase acting on D-2-hydroxyglutarate. Biochem. J. 381 (2004) 35–42. [DOI] [PMID: 15070399] |
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| [EC 1.1.99.39 created 2013] |
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