| EC |
1.1.1.64 |
| Accepted name: |
testosterone 17β-dehydrogenase (NADP+) |
| Reaction: |
testosterone + NADP+ = androstenedione + NADPH + H+ |
| Glossary: |
androstenedione = androst-4-ene-3,17-dione |
| Other name(s): |
17-ketoreductase; NADP-dependent testosterone-17β-oxidoreductase; testosterone 17β-dehydrogenase (NADP) |
| Systematic name: |
17β-hydroxysteroid:NADP+ 17-oxidoreductase |
| Comments: |
Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9028-63-1 |
| References: |
| 1. |
Endahl, G.L., Kochakia, C.D. and Hamm, D. Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine-specific 17β-hydroxy (testosterone) dehydrogenase of guinea pig liver. J. Biol. Chem. 235 (1960) 2792–2796. [PMID: 13696735] |
| 2. |
Sweat, M.L., Samuels, L.T. and Lumry, R. Preparation and characterisation of the enzyme which converts testosterone to androstendione. J. Biol. Chem. 185 (1950) 75–84. [PMID: 15436478] |
| 3. |
Villee, C.A. and Spencer, J.M. Some properties of the pyridine nucleotide-specific 17β-hydroxy steroid dehydrogenase of guinea pig liver. J. Biol. Chem. 235 (1960) 3615–3619. [PMID: 13781425] |
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| [EC 1.1.1.64 created 1965] |
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