| EC |
1.1.1.316 |
| Accepted name: |
L-galactose 1-dehydrogenase (NAD+) |
| Reaction: |
L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+ (overall reaction)
(1a) L-galactose + NAD+ = L-galactono-1,5-lactone + NADH + H+
(1b) L-galactono-1,5-lactone = L-galactono-1,4-lactone (spontaneous) |
| Other name(s): |
L-GalDH; L-galactose dehydrogenase; L-galactose 1-dehydrogenase |
| Systematic name: |
L-galactose:NAD+ 1-oxidoreductase |
| Comments: |
The enzyme catalyses a step in the ascorbate biosynthesis in higher plants (Smirnoff-Wheeler pathway). The activity with NADP+ is less than 10% of the activity with NAD+. cf. EC 1.1.1.445, L-galactose 1-dehydrogenase (NADP+). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Mieda, T., Yabuta, Y., Rapolu, M., Motoki, T., Takeda, T., Yoshimura, K., Ishikawa, T. and Shigeoka, S. Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate. Plant Cell Physiol. 45 (2004) 1271–1279. [DOI] [PMID: 15509850] |
| 2. |
Gatzek, S., Wheeler, G.L. and Smirnoff, N. Antisense suppression of L-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated L-galactose synthesis. Plant J. 30 (2002) 541–553. [DOI] [PMID: 12047629] |
| 3. |
Wheeler, G.L., Jones, M.A. and Smirnoff, N. The biosynthetic pathway of vitamin C in higher plants. Nature 393 (1998) 365–369. [DOI] [PMID: 9620799] |
| 4. |
Oh, M.M., Carey, E.E. and Rajashekar, C.B. Environmental stresses induce health-promoting phytochemicals in lettuce. Plant Physiol. Biochem. 47 (2009) 578–583. [DOI] [PMID: 19297184] |
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| [EC 1.1.1.316 created 2011, modified 2026] |
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