| EC |
1.1.1.273 |
| Accepted name: |
vellosimine dehydrogenase |
| Reaction: |
10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+ |
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For diagram of geissoschizine and sarpagine biosynthesis, click here |
| Systematic name: |
10-deoxysarpagine:NADP+ oxidoreductase |
| Comments: |
Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 86777-26-6 |
| References: |
| 1. |
Pfitzner, A., Krausch, B. and Stöckigt, J. Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine. Tetrahedron 40 (1984) 1691–1699. |
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| [EC 1.1.1.273 created 2002] |
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