| EC |
1.1.1.271 |
| Accepted name: |
GDP-L-fucose synthase |
| Reaction: |
GDP-β-L-fucose + NADP+ = GDP-4-dehydro-α-D-rhamnose + NADPH + H+ |
|
For diagram of GDP-L-Fucose and GDP-mannose biosynthesis, click here |
| Glossary: |
GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose |
| Other name(s): |
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) |
| Systematic name: |
GDP-β-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) |
| Comments: |
Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 113756-18-6 |
| References: |
| 1. |
Chang, S., Duerr, B. and Serif, G. An epimerase-reductase in L-fucose synthesis. J. Biol. Chem. 263 (1988) 1693–1697. [PMID: 3338988] |
| 2. |
Mattila, P., Räbinä, J, Hortling, S., Jelin, J. and Renkonen, R. Functional expression of Escherichia coli enzymes synthesizing GDP-L-fucose from inherent GDP-D-mannose in Saccharomyces cerevisiae. Glycobiology 10 (2000) 1041–1047. [DOI] [PMID: 11030750] |
| 3. |
Menon, S., Stahl, M., Kumar, R., Xu, G.-Y. and Sullivan, F. Stereochemical course and steady state mechanism of the reaction catalyzed by the GDP-fucose synthetase from Escherichia coli. J. Biol. Chem. 274 (1999) 26743–26750. [DOI] [PMID: 10480878] |
| 4. |
Somers, W.S., Stahl, M.L. and Sullivan, F.X. GDP-fucose synthetase from Escherichia coli: Structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site. Structure 6 (1998) 1601–1612. [DOI] [PMID: 9862812] |
|
| [EC 1.1.1.271 created 2002, modified 2003] |
| |
|
| |
|
Printable version