ExplorEnz: EC 1.1.1.251

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1.1.1.251

Accepted name:

galactitol-1-phosphate 5-dehydrogenase

Reaction:

galactitol 1-phosphate + NAD⁺ = D-tagatose 6-phosphate + NADH + H⁺

Other name(s):

gatD (gene name)

Systematic name:

galactitol-1-phosphate:NAD⁺ oxidoreductase

Comments:

The enzyme from the bacterium Escherichia coli is involved in a galactitol degradation pathway. It contains two zinc atoms per subunit.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 60120-43-6

References:

1.	Wolff, J.B., Kaplan, N.O. Hexitol metabolism in Escherichia coli. J. Bacteriol. 71 (1956) 557–564. [PMID: 13331868]
2.	Nobelmann, B. and Lengeler, J.W. Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli. Biochim. Biophys. Acta 1262 (1995) 69–72. [DOI] [PMID: 7772602]
3.	Benavente, R., Esteban-Torres, M., Kohring, G.W., Cortes-Cabrera, A., Sanchez-Murcia, P.A., Gago, F., Acebron, I., de las Rivas, B., Munoz, R. and Mancheno, J.M. Enantioselective oxidation of galactitol 1-phosphate by galactitol-1-phosphate 5-dehydrogenase from Escherichia coli. Acta Crystallogr. D Biol. Crystallogr. 71 (2015) 1540–1554. [DOI] [PMID: 26143925]

[EC 1.1.1.251 created 1999]