| EC |
1.1.1.247 |
| Accepted name: |
codeinone reductase (NADPH) |
| Reaction: |
codeine + NADP+ = codeinone + NADPH + H+ |
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For diagram of morphine biosynthesis, click here |
| Systematic name: |
codeine:NADP+ oxidoreductase |
| Comments: |
Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 153302-41-1 |
| References: |
| 1. |
Lenz, R. and Zenk, M.H. Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum. Tetrahedron Lett. 36 (1995) 2449–2452. |
| 2. |
Lenz, R. and Zenk, M.H. Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures. Eur. J. Biochem. 233 (1995) 132–139. [DOI] [PMID: 7588736] |
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| [EC 1.1.1.247 created 1999, modified 2001] |
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