| EC |
1.1.1.238 |
| Accepted name: |
12β-hydroxysteroid dehydrogenase |
| Reaction: |
3α,7α,12β-trihydroxy-5β-cholan-24-oate + NADP+ = 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate + NADPH + H+ |
| Other name(s): |
12β-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase |
| Systematic name: |
12β-hydroxysteroid:NADP+ 12-oxidoreductase |
| Comments: |
Acts on a number of bile acids, both in their free and conjugated forms. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 118390-62-8 |
| References: |
| 1. |
Edenharder, R. and Pfützner, A. Characterization of NADP-dependent 12β-hydroxysteroid dehydrogenase from Clostridium paraputrificum. Biochim. Biophys. Acta 962 (1988) 362–370. [DOI] [PMID: 3167086] |
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| [EC 1.1.1.238 created 1992] |
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