ExplorEnz: EC 1.1.1.205

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1.1.1.205

Accepted name:

IMP dehydrogenase

Reaction:

IMP + NAD⁺ + H₂O = XMP + NADH + H⁺

For diagram of AMP and GMP biosynthesis, click here

Glossary:

IMP = inosine 5′-phosphate
XMP = xanthosine 5′-phosphate

Other name(s):

inosine-5′-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5′-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase

Systematic name:

IMP:NAD⁺ oxidoreductase

Comments:

The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9028-93-7

References:

1.	Magasanik, B., Moyed, H.S. and Gehring, L.B. Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5′-phosphate dehydrogenase of Aerobacter aerogenes. J. Biol. Chem. 226 (1957) 339–350. [PMID: 13428767]
2.	Turner, J.F. and King, J.E. Inosine 5-phosphate dehydrogenase of pea seeds. Biochem. J. 79 (1961) 147. [PMID: 13778733]

[EC 1.1.1.205 created 1961 as EC 1.2.1.14, transferred 1984 to EC 1.1.1.205]