| EC |
1.1.1.159 |
| Accepted name: |
7α-hydroxysteroid dehydrogenase |
| Reaction: |
cholate + NAD+ = 3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate + NADH + H+ |
| Glossary: |
cholate = 3α,7α,12α-trihydroxy-5β-cholan-24-oate |
| Other name(s): |
7α-hydroxy steroid dehydrogenase; 7α-HSDH |
| Systematic name: |
7α-hydroxysteroid:NAD+ 7-oxidoreductase |
| Comments: |
Catalyses the oxidation of the 7α-hydroxy group of bile acids and alcohols both in their free and conjugated forms. The Bacteroides fragilis and Clostridium enzymes can also utilize NADP+. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 39361-64-3 |
| References: |
| 1. |
Haslewood, E.S. and Haslewood, G.A.D. The specificity of a 7α-hydroxy steroid dehydrogenase from Escherichia coli. Biochem. J. 157 (1976) 207–210. [PMID: 786279] |
| 2. |
Macdonald, I.A. and Roach, P.D. Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum. Biochim. Biophys. Acta 665 (1981) 262–269. [DOI] [PMID: 6945134] |
| 3. |
Macdonald, I.A., Williams, C.N. and Mahony, D.E. 7α-Hydroxysteroid dehydrogenase from Escherichia coli B: preliminary studies. Biochim. Biophys. Acta 309 (1973) 243–253. [DOI] [PMID: 4581498] |
| 4. |
Macdonald, I.A., Williams, C.N., Mahony, D.E. and Christie, W.M. NAD- and NADP-dependent 7α-hydroxysteroid dehydrogenases from Bacteroides fragilis. Biochim. Biophys. Acta 384 (1975) 12–24. [DOI] [PMID: 236764] |
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| [EC 1.1.1.159 created 1976, modified 1980] |
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