Dolichyltetradecasaccharide Biosynthesis

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The monosaccharide residue just added in each reaction is highlighted in bold type.

© IUBMB 2011


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EC 2.4.1.131 GDP-Man:Man3GlcNAc2-PP-Dol α-1,2-mannosyltransferase
EC 2.4.1.132 GDP-Man:Man1GlcNAc2-PP-Dol α-1,3-mannosyltransferase
EC 2.4.1.141 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
EC 2.4.1.142 chitobiosyldiphosphodolichol β-mannosyltransferase
EC 2.4.1.256 Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol α-1,2-glucosyltransferase
EC 2.4.1.257 GDP-Man:Man2GlcNAc2-PP-Dol α-1,6-mannosyltransferase
EC 2.4.1.258 Dol-P-Man:Man5GlcNAc2-PP-Dol α-1,3-mannosyltransferase
EC 2.4.1.259 Dol-P-Man:Man6GlcNAc2-PP-Dol α-1,2-mannosyltransferase
EC 2.4.1.260 Dol-P-Man:Man7GlcNAc2-PP-Dol α-1,6-mannosyltransferase
EC 2.4.1.261 Dol-P-Man:Man8GlcNAc2-PP-Dol α-1,2-mannosyltransferase
EC 2.4.1.265 Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol α-1,3-glucosyltransferase
EC 2.4.1.267 Dol-P-Glc:Man9GlcNAc2-PP-Dol α-1,3-glucosyltransferase
EC 2.7.8.15 UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase