ExplorEnz: Changes log The Enzyme Database


 

Changes Log

The entries in the log are arranged in chronological order, with the most recent changes at the top. If you wish to search for changes to a particular enzyme, then enter ec:x.y.z.w (repacing x.y.z.w by the relevant EC number) in the search text box at the top of the page. Other terms can be entered in the text box to limit the results obtained.



<< Previous | Next >>

ID Date/Time EC/Citation Key Table Field Changed From Changed To
 1  2005-08-10 17:09:22  3.4.11.1  entry  cas_num  9001-61-0,90119-07-6  9001-61-0, 90119-07-6
 8  2005-08-11 14:53:58  3.4.13.5  entry  cas_num  9027-38-7,37289-11-5  9027-38-7, 37289-11-5
 15  2005-08-12 08:50:10  3.4.11.4  entry  comments  A zinc enzyme, widely distributed in mammalian tissues. Formerly EC 3.4.1.3  A zinc enzyme, widely distributed in mammalian tissues. Formerly EC 3.4.1.3 EC 1.1.1.1
 19  2005-08-12 10:44:59  2.4.2.21  entry  common_name  nicotinate-nucleotide&#151;dimethylbenzimidazole phosphoribosyltransferase  nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase
 25  2005-08-18 08:29:12  2.4.2.21  entry  common_name  nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase  nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase bonkers
 27  2005-08-18 08:40:55  2.4.2.21  entry  common_name  nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase bonkers  nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase
 32  2005-11-11 18:01:15  1.1.1.1  entry  other_names  aldehyde reductase; ADH; alcohol dehydrogenase (NAD+); aliphatic alcohol dehydrogenase; ethanol dehydrogenase; NAD+-dependent alcohol dehydrogenase; NAD+-specific aromatic alcohol dehydrogenase; NADH-alcohol dehydrogenase; NADH-aldehyde dehydrogenase; primary alcohol dehydrogenase; yeast alcohol dehydrogenase  ADH; alcohol dehydrogenase (NAD+); aldehyde reductase; aliphatic alcohol dehydrogenase; ethanol dehydrogenase; NAD+-dependent alcohol dehydrogenase; NAD+-specific aromatic alcohol dehydrogenase; NADH-alcohol dehydrogenase; NADH-aldehyde dehydrogenase; primary alcohol dehydrogenase; yeast alcohol dehydrogenase
 35  2005-11-13 17:47:26  2.6.1.76  entry  common_name  diaminobutyrate&#151;2-oxoglutarate transaminase  diaminobutyrate—2-oxoglutarate transaminase
 36  2005-11-13 17:47:26  2.6.1.76  entry  reaction  L-2,4-diaminobutyrate + 2-oxoglutarate = L-glutamate + L-aspartic 4-semialdehyde  L-2,4-diaminobutyrate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate
 37  2005-11-13 17:47:26  2.6.1.76  entry  other_names  L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase; 2,4-diaminobutyrate 4-aminotransferase   L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase; 2,4-diaminobutyrate 4-aminotransferase; diaminobutyrate aminotransferase; DABA aminotransferase; DAB aminotransferase; EctB; diaminibutyric acid aminotransferase
 38  2005-11-13 17:47:26  2.6.1.76  entry  comments  Involved in the formation of 1,3-diaminopropane in Haemophilus influenzae and Acinetobacter baumannii. A product of the ddc gene that also encodes L-2,4-diaminobutyrate decarboxylase in Acinetobacter baumannii. Differs from EC 2.6.1.46 diaminobutyrate-pyruvate transaminase, which has pyruvate as the amino-group acceptor.  A pyridoxal-phosphate protein that requires potassium for activity [4]. Involved in the formation of 1,3-diaminopropane in Haemophilus influenzae and Acinetobacter baumannii. A product of the ddc gene that also encodes L-2,4-diaminobutyrate decarboxylase in Acinetobacter baumannii. Differs from EC 2.6.1.46 diaminobutyrate-pyruvate transaminase, which has pyruvate as the amino-group acceptor. This is the first enzyme in the ectoine biosynthesis pathway, the other enzymes involved being EC 2.5.1.74, diaminobutyrate acetyltransferase and 4.2.1.108, ectoine synthase [3,4].
 45  2005-11-15 09:52:53  2.6.1.76  entry  common_name  diaminobutyrate—2-oxoglutarate transaminase  diaminobutyrate---2-oxoglutarate transaminase
 55  2005-11-24 08:02:27  3.2.1.83  entry  reaction  Hydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in various carrageenans  Endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans
 56  2005-11-24 08:02:27  3.2.1.83  entry  other_names     kappa-carrageenan 4-beta-D-glycanohydrolase
 57  2005-11-24 08:02:27  3.2.1.83  entry  sys_name  kappa-carrageenan 4-beta-D-glycanohydrolase  kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining)
 58  2005-11-24 08:02:27  3.2.1.83  entry  comments  Dominant products are the oligomers [3-O-(3,6-anhydro-alpha-D-galactopyranosyl)-D-galactose 4-O-sulfate]1-4.  The main products of hydrolysis are neocarrabiose-sulfate and neocarratetraose-sulfate [5]. Unlike EC 3.2.1.157 (ι-carrageenase), but similar to EC 3.2.1.83 ( agarase), this enzyme proceeds with retention of the anomeric configuration.
 68  2005-11-24 11:38:50  3.2.1.83  entry  comments  The main products of hydrolysis are neocarrabiose-sulfate and neocarratetraose-sulfate [5]. Unlike EC 3.2.1.157 (ι-carrageenase), but similar to EC 3.2.1.83 ( agarase), this enzyme proceeds with retention of the anomeric configuration.  The main products of hydrolysis are neocarrabiose-sulfate and neocarratetraose-sulfate [5]. Unlike EC 3.2.1.157 (iota-carrageenase), but similar to EC 3.2.1.83 ( agarase), this enzyme proceeds with retention of the anomeric configuration.
 85  2005-11-28 10:27:04    entry  ec_num    1.13.11.51
 86  2005-11-28 10:27:04    entry  common_name    9-cis-epoxycarotenoid dioxygenase
 87  2005-11-28 10:27:04    entry  reaction    (1) a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal;;(2) 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-β-caroten-12'-al;;(3) 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-β-caroten-12'-al
 88  2005-11-28 10:27:04    entry  other_names    nine-cis-epoxycarotenoid dioxygenase; NCED; AtNCED3; PvNCED1; VP14
 89  2005-11-28 10:27:04    entry  sys_name    9-cis-epoxycarotenoid 11,12-dioxygenase
 90  2005-11-28 10:27:04    entry  comments     Requires iron(II). Acts on 9-cis-violaxanthin and 9'-cis-neoxanthin but not on the all-trans isomers [2,3]. In vitro, it will cleave 9-cis-zeaxanthin. Catalyses the first step of abscisic-acid biosynthesis from carotenoids in chloroplasts, in response to water stress. The other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic aldehyde oxidase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase].
 91  2005-11-28 10:27:04    entry  links    
 92  2005-11-28 10:27:04    entry  class    1
 93  2005-11-28 10:27:04    entry  subclass    13
 94  2005-11-28 10:27:04    entry  subsubclass    11
 95  2005-11-28 10:27:04    entry  serial    51
 97  2005-11-28 10:27:04    entry  diagram    
 98  2005-11-28 10:27:04    entry  cas_num    
 115  2005-12-06 12:09:47  1.3.1.72  entry  glossary    desmosterol = cholesta-5,24-dien-3beta-ol<br> <a href="http://www.chem.qmul.ac.uk/iupac/sectionF/terp2.html#K" target="new">lanosterol</a> = 4,4,14-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol<br> zymostrol = 5alpha-cholesta-8,24-dien-3beta-ol
 157  2005-12-08 07:27:33  3.2.1.81  entry  common_name  agarase  beta-agarase
 158  2005-12-08 07:27:33  3.2.1.81  entry  reaction  Hydrolysis of 1,3-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product  Hydrolysis of 1,4-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product
 159  2005-12-08 07:27:33  3.2.1.81  entry  other_names  beta-agarase  agarase (ambiguous); AgaA; AgaB; endo-beta-agarase; agarose 3-glycanohydrolase (incorrect)
 160  2005-12-08 07:27:33  3.2.1.81  entry  sys_name  agarose 3-glycanohydrolase  agarose 4-glycanohydrolase
 161  2005-12-08 07:27:33  3.2.1.81  entry  comments  Also acts on porphyran.  Also acts on porphyran, but more slowly [1]. This enzyme cleaves the beta-(1->4) linkages of agarose in a random manner with retention of the anomeric-bond configuration, producing beta-anomers that give rise progressively to alpha-anomers when mutarotation takes place [6]. The end products of hydrolysis are neoagarotetraose and neoagarohexaose in the case of AgaA from the marine bacterium Zobellia galactanivorans, and neoagarotetraose and neoagarobiose in the case of AgaB [6].
 170  2005-12-08 09:43:15  3.2.1.81  entry  glossary    <a href="http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/agarose.html" target = "new"> agarose</a>: a polysaccharide<br> In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not. For example: neoagarobiose = 3,6-anhydro-alpha-L-galactopyranosyl-(1->3)-D-galactose agarobiose = beta-D-galactopyranosyl-(1->4)-3,6-anhydro-L-galactose
 172  2005-12-08 09:45:34  3.2.1.83  entry  glossary    In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not.<br> For example:<br> iota-neocarrabiose = 3,6-anhydro-2-O-sulfo-alpha-D-galactopyranosyl-(1->3)-4-O-sulfo-D-galactose<br> iota-carrabiose = 4-O-sulfo- beta-D-galactopyranosyl-(1->4)-3,6-anhydro-2-O-sulfo-D-galactose
 182  2005-12-08 09:57:36  3.2.1.157  entry  ec_num    3.2.1.157
 183  2005-12-08 09:57:36  3.2.1.157  entry  common_name    iota-carrageenase
 184  2005-12-08 09:57:36  3.2.1.157  entry  reaction    Endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans
 185  2005-12-08 09:57:36  3.2.1.157  entry  other_names    
 186  2005-12-08 09:57:36  3.2.1.157  entry  sys_name    iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting)
 187  2005-12-08 09:57:36  3.2.1.157  entry  comments     The main products of hydrolysis are iota-neocarratetraose sulfate and iota-neocarrahexaose sulfate. iota-Neocarraoctaose is the shortest substrate oligomer that can be cleaved. Unlike EC 3.2.1.81, beta-agarase and EC 3.2.1.83, kappa-carrageenase, this enzyme proceeds with inversion of the anomeric configuration. iota-Carrageenan differs from kappa-carrageenan by possessing a sulfo group on O-2 of the 3,6-anhydro-D-galactose residues, in addition to that present in the kappa-compound on O-4 of the D-galactose residues.
 188  2005-12-08 09:57:36  3.2.1.157  entry  links    
 189  2005-12-08 09:57:36  3.2.1.157  entry  class    3
 190  2005-12-08 09:57:36  3.2.1.157  entry  subclass    2
 191  2005-12-08 09:57:36  3.2.1.157  entry  subsubclass    1
 192  2005-12-08 09:57:36  3.2.1.157  entry  serial    157
 194  2005-12-08 09:57:36  3.2.1.157  entry  diagram    
 195  2005-12-08 09:57:36  3.2.1.157  entry  cas_num    
 205  2005-12-08 09:57:36  3.2.1.157  entry  glossary    In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not.<br> For example:<br> iota-neocarrabiose = 3,6-anhydro-2-O-sulfo-alpha-D-galactopyranosyl-(1->3)-4-O-sulfo-D-galactose<br> iota-carrabiose = 4-O-sulfo-beta-D-galactopyranosyl-(1->4)-3,6-anhydro-2-O-sulfo-D-galactose
 209  2005-12-08 10:16:42  3.2.1.158  entry  ec_num    3.2.1.158
 210  2005-12-08 10:16:42  3.2.1.158  entry  common_name    alpha-agarase
 211  2005-12-08 10:16:42  3.2.1.158  entry  reaction    Endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product
 212  2005-12-08 10:16:42  3.2.1.158  entry  other_names    agarase (ambiguous); agaraseA33
 213  2005-12-08 10:16:42  3.2.1.158  entry  sys_name    agarose 3-glycanohydrolase
 214  2005-12-08 10:16:42  3.2.1.158  entry  comments    Requires Ca2+. The enzyme from Thalassomonas sp. can use agarose, agarohexaose and neoagarohexaose as substrate. The products of agarohexaose hydrolysis are dimers and tetramers, with agarotetraose being the predominant product, whereas hydrolysis of neoagarohexaose gives rise to two types of trimer. While the enzyme can also hydrolyse the highly sulfated agarose porphyran very efficiently, it cannot hydrolyse the related compounds kappa-carrageenan (see EC 3.2.1.83) and iota-carrageenan (see EC 3.2.1.157) [2]. See also EC 3.2.1.81, beta-agarase.
 215  2005-12-08 10:16:42  3.2.1.158  entry  links    
 216  2005-12-08 10:16:42  3.2.1.158  entry  class    3
 217  2005-12-08 10:16:42  3.2.1.158  entry  subclass    2
 218  2005-12-08 10:16:42  3.2.1.158  entry  subsubclass    1
 219  2005-12-08 10:16:42  3.2.1.158  entry  serial    158
 221  2005-12-08 10:16:42  3.2.1.158  entry  diagram    
 222  2005-12-08 10:16:42  3.2.1.158  entry  cas_num    
 232  2005-12-08 10:16:42  3.2.1.158  entry  glossary    <a href="http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/agarose.html" target = "new">agarose</a>: a polysaccharide<br> In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not.<br> For example:<br> neoagarobiose = 3,6-anhydro-alpha-L-galactopyranosyl-(1->3)-D-galactose<br> agarobiose = beta-D-galactopyranosyl-(1->4)-3,6-anhydro-L-galactose<br>
 235  2005-12-08 10:22:28  3.2.1.159  entry  ec_num    3.2.1.159
 236  2005-12-08 10:22:28  3.2.1.159  entry  common_name     alpha-neoagaro-oligosaccharide hydrolase
 237  2005-12-08 10:22:28  3.2.1.159  entry  reaction    Hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose
 238  2005-12-08 10:22:28  3.2.1.159  entry  other_names    alpha-neoagarooligosaccharide hydrolase; alpha-NAOS hydrolase
 239  2005-12-08 10:22:28  3.2.1.159  entry  sys_name    neoagaro-oligosaccharide 3-glycohydrolase
 240  2005-12-08 10:22:28  3.2.1.159  entry  comments    When neoagarohexaose is used as a substrate, the oligosaccharide is cleaved at the non-reducing end to produce 3,6-anhydro-L-galactose and agaropentaose, which is further hydrolysed to agarobiose and agarotriose. With neoagarotetraose as substrate, the products are predominantly agarotriose and 3,6-anhydro-L-galactose. In Vibrio sp. the actions of EC 3.2.1.81, beta-agarase and EC 3.2.1.159 can be used to degrade agarose to 3,6-anhydro-L-galactose and D-galactose.
 241  2005-12-08 10:22:28  3.2.1.159  entry  links    
 242  2005-12-08 10:22:28  3.2.1.159  entry  class    3
 243  2005-12-08 10:22:28  3.2.1.159  entry  subclass    2
 244  2005-12-08 10:22:28  3.2.1.159  entry  subsubclass    1
 245  2005-12-08 10:22:28  3.2.1.159  entry  serial    159
 247  2005-12-08 10:22:28  3.2.1.159  entry  diagram    
 248  2005-12-08 10:22:28  3.2.1.159  entry  cas_num    
 258  2005-12-08 10:22:28  3.2.1.159  entry  glossary    In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not.<br> For example:<br> neoagarobiose = 3,6-anhydro-alpha-L-galactopyranosyl-(1->3)-D-galactose<br> agarobiose = beta-D-galactopyranosyl-(1->4)-3,6-anhydro-L-galactose
 287  2005-12-08 10:32:33  3.5.1.94  entry  ec_num    3.5.1.94
 288  2005-12-08 10:32:33  3.5.1.94  entry  common_name    gamma-glutamyl-gamma-aminobutyrate hydrolase
 289  2005-12-08 10:32:33  3.5.1.94  entry  reaction    4-(gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate
 290  2005-12-08 10:32:33  3.5.1.94  entry  other_names    gamma-glutamyl-GABA hydrolase; PuuD; YcjL
 291  2005-12-08 10:32:33  3.5.1.94  entry  sys_name    4-(gamma-glutamylamino)butanoate amidohydrolase
 292  2005-12-08 10:32:33  3.5.1.94  entry  comments     Forms part of a novel putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form gamma-glutamylputrescine, which is oxidized to 4-(gamma-glutamylamino)butanal and then to 4-(γ-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase).
 293  2005-12-08 10:32:33  3.5.1.94  entry  links    
 294  2005-12-08 10:32:33  3.5.1.94  entry  class    3
 295  2005-12-08 10:32:33  3.5.1.94  entry  subclass    5
 296  2005-12-08 10:32:33  3.5.1.94  entry  subsubclass    1
 297  2005-12-08 10:32:33  3.5.1.94  entry  serial    94
 299  2005-12-08 10:32:33  3.5.1.94  entry  diagram    
 300  2005-12-08 10:32:33  3.5.1.94  entry  cas_num    
 310  2005-12-08 10:32:33  3.5.1.94  entry  glossary    
 338  2005-12-08 10:34:59  1.1.1.289  entry  ec_num    1.1.1.289
 339  2005-12-08 10:34:59  1.1.1.289  entry  common_name    sorbose reductase
 340  2005-12-08 10:34:59  1.1.1.289  entry  reaction    D-sorbitol + NADP+ = L-sorbose + NADPH + H+
 341  2005-12-08 10:34:59  1.1.1.289  entry  other_names    Sou1p
 342  2005-12-08 10:34:59  1.1.1.289  entry  sys_name    D-sorbitol:NADP+ oxidoreductase
 343  2005-12-08 10:34:59  1.1.1.289  entry  comments    The reaction occurs predominantly in the reverse direction. This enzyme can also convert fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.
 344  2005-12-08 10:34:59  1.1.1.289  entry  links    
 345  2005-12-08 10:34:59  1.1.1.289  entry  class    1
 346  2005-12-08 10:34:59  1.1.1.289  entry  subclass    1
 347  2005-12-08 10:34:59  1.1.1.289  entry  subsubclass    1
 348  2005-12-08 10:34:59  1.1.1.289  entry  serial    289
 350  2005-12-08 10:34:59  1.1.1.289  entry  diagram    
 351  2005-12-08 10:34:59  1.1.1.289  entry  cas_num    
 361  2005-12-08 10:34:59  1.1.1.289  entry  glossary    
 594  2005-12-08 12:10:17  1.14.13.101  entry  ec_num    1.14.13.101
 595  2005-12-08 12:10:17  1.14.13.101  entry  common_name    senecionine N-oxygenase
 596  2005-12-08 12:10:17  1.14.13.101  entry  reaction     senecionine + NADPH + H+ + O2 = senecionine N-oxide + NADP+ + H2O
 597  2005-12-08 12:10:17  1.14.13.101  entry  other_names    senecionine monooxygenase (N-oxide-forming); SNO
 598  2005-12-08 12:10:17  1.14.13.101  entry  sys_name    senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming)
 599  2005-12-08 12:10:17  1.14.13.101  entry  comments    A flavoprotein. NADH cannot replace NADPH. While pyrrolizidine alkaloids of the senecionine and monocrotaline types are generally good substrates (e.g. senecionine, retrorsine and monocrotaline), the enzyme does not use ester alkaloids lacking an hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-alkaloids (e.g. sarracine) or unesterified necine bases (e.g. senkirkine) as substrates [1]. Senecionine N-oxide is used by insects as a chemical defense: senecionine N-oxide is non-toxic, but it is bioactivated to a toxic form by the action of cytochrome P-450 oxidase when absorbed by insectivores.
 600  2005-12-08 12:10:17  1.14.13.101  entry  links    

Return to top
© 2005-2024 IUBMB