|
ID |
Date/Time |
EC/Citation Key |
Table |
Field |
Changed From |
Changed To |
1 |
2005-08-10 17:09:22 |
3.4.11.1 |
entry |
cas_num |
9001-61-0,90119-07-6 |
9001-61-0, 90119-07-6 |
8 |
2005-08-11 14:53:58 |
3.4.13.5 |
entry |
cas_num |
9027-38-7,37289-11-5 |
9027-38-7, 37289-11-5 |
15 |
2005-08-12 08:50:10 |
3.4.11.4 |
entry |
comments |
A zinc enzyme, widely distributed in mammalian tissues. Formerly EC 3.4.1.3 |
A zinc enzyme, widely distributed in mammalian tissues. Formerly EC 3.4.1.3 EC 1.1.1.1 |
19 |
2005-08-12 10:44:59 |
2.4.2.21 |
entry |
common_name |
nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase |
nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase |
25 |
2005-08-18 08:29:12 |
2.4.2.21 |
entry |
common_name |
nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase |
nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase bonkers |
27 |
2005-08-18 08:40:55 |
2.4.2.21 |
entry |
common_name |
nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase bonkers |
nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase |
32 |
2005-11-11 18:01:15 |
1.1.1.1 |
entry |
other_names |
aldehyde reductase; ADH; alcohol dehydrogenase (NAD+); aliphatic alcohol dehydrogenase; ethanol dehydrogenase; NAD+-dependent alcohol dehydrogenase; NAD+-specific aromatic alcohol dehydrogenase; NADH-alcohol dehydrogenase; NADH-aldehyde dehydrogenase; primary alcohol dehydrogenase; yeast alcohol dehydrogenase |
ADH; alcohol dehydrogenase (NAD+); aldehyde reductase; aliphatic alcohol dehydrogenase; ethanol dehydrogenase; NAD+-dependent alcohol dehydrogenase; NAD+-specific aromatic alcohol dehydrogenase; NADH-alcohol dehydrogenase; NADH-aldehyde dehydrogenase; primary alcohol dehydrogenase; yeast alcohol dehydrogenase |
35 |
2005-11-13 17:47:26 |
2.6.1.76 |
entry |
common_name |
diaminobutyrate—2-oxoglutarate transaminase |
diaminobutyrate—2-oxoglutarate transaminase |
36 |
2005-11-13 17:47:26 |
2.6.1.76 |
entry |
reaction |
L-2,4-diaminobutyrate + 2-oxoglutarate = L-glutamate + L-aspartic 4-semialdehyde |
L-2,4-diaminobutyrate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate |
37 |
2005-11-13 17:47:26 |
2.6.1.76 |
entry |
other_names |
L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase; 2,4-diaminobutyrate 4-aminotransferase |
L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase; 2,4-diaminobutyrate 4-aminotransferase; diaminobutyrate aminotransferase; DABA aminotransferase; DAB aminotransferase; EctB; diaminibutyric acid aminotransferase |
38 |
2005-11-13 17:47:26 |
2.6.1.76 |
entry |
comments |
Involved in the formation of 1,3-diaminopropane in Haemophilus influenzae and Acinetobacter baumannii. A product of the ddc gene that also encodes L-2,4-diaminobutyrate decarboxylase in Acinetobacter baumannii. Differs from EC 2.6.1.46 diaminobutyrate-pyruvate transaminase, which has pyruvate as the amino-group acceptor. |
A pyridoxal-phosphate protein that requires potassium for activity [4]. Involved in the formation of 1,3-diaminopropane in Haemophilus influenzae and Acinetobacter baumannii. A product of the ddc gene that also encodes L-2,4-diaminobutyrate decarboxylase in Acinetobacter baumannii. Differs from EC 2.6.1.46 diaminobutyrate-pyruvate transaminase, which has pyruvate as the amino-group acceptor. This is the first enzyme in the ectoine biosynthesis pathway, the other enzymes involved being EC 2.5.1.74, diaminobutyrate acetyltransferase and 4.2.1.108, ectoine synthase [3,4]. |
45 |
2005-11-15 09:52:53 |
2.6.1.76 |
entry |
common_name |
diaminobutyrate—2-oxoglutarate transaminase |
diaminobutyrate---2-oxoglutarate transaminase |
55 |
2005-11-24 08:02:27 |
3.2.1.83 |
entry |
reaction |
Hydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in various carrageenans |
Endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans |
56 |
2005-11-24 08:02:27 |
3.2.1.83 |
entry |
other_names |
|
kappa-carrageenan 4-beta-D-glycanohydrolase |
57 |
2005-11-24 08:02:27 |
3.2.1.83 |
entry |
sys_name |
kappa-carrageenan 4-beta-D-glycanohydrolase |
kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) |
58 |
2005-11-24 08:02:27 |
3.2.1.83 |
entry |
comments |
Dominant products are the oligomers [3-O-(3,6-anhydro-alpha-D-galactopyranosyl)-D-galactose 4-O-sulfate]1-4. |
The main products of hydrolysis are neocarrabiose-sulfate and neocarratetraose-sulfate [5]. Unlike EC 3.2.1.157 (ι-carrageenase), but similar to EC 3.2.1.83 ( agarase), this enzyme proceeds with retention of the anomeric configuration. |
68 |
2005-11-24 11:38:50 |
3.2.1.83 |
entry |
comments |
The main products of hydrolysis are neocarrabiose-sulfate and neocarratetraose-sulfate [5]. Unlike EC 3.2.1.157 (ι-carrageenase), but similar to EC 3.2.1.83 ( agarase), this enzyme proceeds with retention of the anomeric configuration. |
The main products of hydrolysis are neocarrabiose-sulfate and neocarratetraose-sulfate [5]. Unlike EC 3.2.1.157 (iota-carrageenase), but similar to EC 3.2.1.83 ( agarase), this enzyme proceeds with retention of the anomeric configuration. |
85 |
2005-11-28 10:27:04 |
|
entry |
ec_num |
|
1.13.11.51 |
86 |
2005-11-28 10:27:04 |
|
entry |
common_name |
|
9-cis-epoxycarotenoid dioxygenase |
87 |
2005-11-28 10:27:04 |
|
entry |
reaction |
|
(1) a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal;;(2) 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-β-caroten-12'-al;;(3) 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-β-caroten-12'-al |
88 |
2005-11-28 10:27:04 |
|
entry |
other_names |
|
nine-cis-epoxycarotenoid dioxygenase; NCED; AtNCED3; PvNCED1; VP14 |
89 |
2005-11-28 10:27:04 |
|
entry |
sys_name |
|
9-cis-epoxycarotenoid 11,12-dioxygenase |
90 |
2005-11-28 10:27:04 |
|
entry |
comments |
|
Requires iron(II). Acts on 9-cis-violaxanthin and 9'-cis-neoxanthin but not on the all-trans isomers [2,3]. In vitro, it will cleave 9-cis-zeaxanthin. Catalyses the first step of abscisic-acid biosynthesis from carotenoids in chloroplasts, in response to water stress. The other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic aldehyde oxidase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase]. |
91 |
2005-11-28 10:27:04 |
|
entry |
links |
|
|
92 |
2005-11-28 10:27:04 |
|
entry |
class |
|
1 |
93 |
2005-11-28 10:27:04 |
|
entry |
subclass |
|
13 |
94 |
2005-11-28 10:27:04 |
|
entry |
subsubclass |
|
11 |
95 |
2005-11-28 10:27:04 |
|
entry |
serial |
|
51 |
97 |
2005-11-28 10:27:04 |
|
entry |
diagram |
|
|
98 |
2005-11-28 10:27:04 |
|
entry |
cas_num |
|
|
115 |
2005-12-06 12:09:47 |
1.3.1.72 |
entry |
glossary |
|
desmosterol = cholesta-5,24-dien-3beta-ol<br>
<a href="http://www.chem.qmul.ac.uk/iupac/sectionF/terp2.html#K" target="new">lanosterol</a> = 4,4,14-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol<br>
zymostrol = 5alpha-cholesta-8,24-dien-3beta-ol |
157 |
2005-12-08 07:27:33 |
3.2.1.81 |
entry |
common_name |
agarase |
beta-agarase |
158 |
2005-12-08 07:27:33 |
3.2.1.81 |
entry |
reaction |
Hydrolysis of 1,3-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product |
Hydrolysis of 1,4-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product |
159 |
2005-12-08 07:27:33 |
3.2.1.81 |
entry |
other_names |
beta-agarase |
agarase (ambiguous); AgaA; AgaB; endo-beta-agarase; agarose 3-glycanohydrolase (incorrect) |
160 |
2005-12-08 07:27:33 |
3.2.1.81 |
entry |
sys_name |
agarose 3-glycanohydrolase |
agarose 4-glycanohydrolase |
161 |
2005-12-08 07:27:33 |
3.2.1.81 |
entry |
comments |
Also acts on porphyran. |
Also acts on porphyran, but more slowly [1]. This enzyme cleaves the beta-(1->4) linkages of agarose in a random manner with retention of the anomeric-bond configuration, producing beta-anomers that give rise progressively to alpha-anomers when mutarotation takes place [6]. The end products of hydrolysis are neoagarotetraose and neoagarohexaose in the case of AgaA from the marine bacterium Zobellia galactanivorans, and neoagarotetraose and neoagarobiose in the case of AgaB [6]. |
170 |
2005-12-08 09:43:15 |
3.2.1.81 |
entry |
glossary |
|
<a href="http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/agarose.html" target = "new"> agarose</a>: a polysaccharide<br>
In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not.
For example:
neoagarobiose = 3,6-anhydro-alpha-L-galactopyranosyl-(1->3)-D-galactose
agarobiose = beta-D-galactopyranosyl-(1->4)-3,6-anhydro-L-galactose |
172 |
2005-12-08 09:45:34 |
3.2.1.83 |
entry |
glossary |
|
In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not.<br>
For example:<br>
iota-neocarrabiose = 3,6-anhydro-2-O-sulfo-alpha-D-galactopyranosyl-(1->3)-4-O-sulfo-D-galactose<br>
iota-carrabiose = 4-O-sulfo- beta-D-galactopyranosyl-(1->4)-3,6-anhydro-2-O-sulfo-D-galactose |
182 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
ec_num |
|
3.2.1.157 |
183 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
common_name |
|
iota-carrageenase |
184 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
reaction |
|
Endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans |
185 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
other_names |
|
|
186 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
sys_name |
|
iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) |
187 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
comments |
|
The main products of hydrolysis are iota-neocarratetraose sulfate and iota-neocarrahexaose sulfate. iota-Neocarraoctaose is the shortest substrate oligomer that can be cleaved. Unlike EC 3.2.1.81, beta-agarase and EC 3.2.1.83, kappa-carrageenase, this enzyme proceeds with inversion of the anomeric configuration. iota-Carrageenan differs from kappa-carrageenan by possessing a sulfo group on O-2 of the 3,6-anhydro-D-galactose residues, in addition to that present in the kappa-compound on O-4 of the D-galactose residues. |
188 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
links |
|
|
189 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
class |
|
3 |
190 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
subclass |
|
2 |
191 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
subsubclass |
|
1 |
192 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
serial |
|
157 |
194 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
diagram |
|
|
195 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
cas_num |
|
|
205 |
2005-12-08 09:57:36 |
3.2.1.157 |
entry |
glossary |
|
In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not.<br>
For example:<br>
iota-neocarrabiose = 3,6-anhydro-2-O-sulfo-alpha-D-galactopyranosyl-(1->3)-4-O-sulfo-D-galactose<br>
iota-carrabiose = 4-O-sulfo-beta-D-galactopyranosyl-(1->4)-3,6-anhydro-2-O-sulfo-D-galactose |
209 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
ec_num |
|
3.2.1.158 |
210 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
common_name |
|
alpha-agarase |
211 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
reaction |
|
Endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product |
212 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
other_names |
|
agarase (ambiguous); agaraseA33 |
213 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
sys_name |
|
agarose 3-glycanohydrolase |
214 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
comments |
|
Requires Ca2+. The enzyme from Thalassomonas sp. can use agarose, agarohexaose and neoagarohexaose as substrate. The products of agarohexaose hydrolysis are dimers and tetramers, with agarotetraose being the predominant product, whereas hydrolysis of neoagarohexaose gives rise to two types of trimer. While the enzyme can also hydrolyse the highly sulfated agarose porphyran very efficiently, it cannot hydrolyse the related compounds kappa-carrageenan (see EC 3.2.1.83) and iota-carrageenan (see EC 3.2.1.157) [2]. See also EC 3.2.1.81, beta-agarase. |
215 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
links |
|
|
216 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
class |
|
3 |
217 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
subclass |
|
2 |
218 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
subsubclass |
|
1 |
219 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
serial |
|
158 |
221 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
diagram |
|
|
222 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
cas_num |
|
|
232 |
2005-12-08 10:16:42 |
3.2.1.158 |
entry |
glossary |
|
<a href="http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/agarose.html" target = "new">agarose</a>: a polysaccharide<br>
In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not.<br>
For example:<br>
neoagarobiose = 3,6-anhydro-alpha-L-galactopyranosyl-(1->3)-D-galactose<br>
agarobiose = beta-D-galactopyranosyl-(1->4)-3,6-anhydro-L-galactose<br> |
235 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
ec_num |
|
3.2.1.159 |
236 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
common_name |
|
alpha-neoagaro-oligosaccharide hydrolase |
237 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
reaction |
|
Hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose |
238 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
other_names |
|
alpha-neoagarooligosaccharide hydrolase; alpha-NAOS hydrolase |
239 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
sys_name |
|
neoagaro-oligosaccharide 3-glycohydrolase |
240 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
comments |
|
When neoagarohexaose is used as a substrate, the oligosaccharide is cleaved at the non-reducing end to produce 3,6-anhydro-L-galactose and agaropentaose, which is further hydrolysed to agarobiose and agarotriose. With neoagarotetraose as substrate, the products are predominantly agarotriose and 3,6-anhydro-L-galactose. In Vibrio sp. the actions of EC 3.2.1.81, beta-agarase and EC 3.2.1.159 can be used to degrade agarose to 3,6-anhydro-L-galactose and D-galactose. |
241 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
links |
|
|
242 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
class |
|
3 |
243 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
subclass |
|
2 |
244 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
subsubclass |
|
1 |
245 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
serial |
|
159 |
247 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
diagram |
|
|
248 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
cas_num |
|
|
258 |
2005-12-08 10:22:28 |
3.2.1.159 |
entry |
glossary |
|
In the field of oligosaccharides derived from agarose, carrageenans, etc., in which alternate residues are 3,6-anhydro sugars, the prefix 'neo' designates an oligosaccharide whose non-reducing end is the anhydro sugar, and the absence of this prefix means that it is not.<br>
For example:<br>
neoagarobiose = 3,6-anhydro-alpha-L-galactopyranosyl-(1->3)-D-galactose<br>
agarobiose = beta-D-galactopyranosyl-(1->4)-3,6-anhydro-L-galactose |
287 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
ec_num |
|
3.5.1.94 |
288 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
common_name |
|
gamma-glutamyl-gamma-aminobutyrate hydrolase |
289 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
reaction |
|
4-(gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate |
290 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
other_names |
|
gamma-glutamyl-GABA hydrolase; PuuD; YcjL |
291 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
sys_name |
|
4-(gamma-glutamylamino)butanoate amidohydrolase |
292 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
comments |
|
Forms part of a novel putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form gamma-glutamylputrescine, which is oxidized to 4-(gamma-glutamylamino)butanal and then to 4-(γ-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase). |
293 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
links |
|
|
294 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
class |
|
3 |
295 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
subclass |
|
5 |
296 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
subsubclass |
|
1 |
297 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
serial |
|
94 |
299 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
diagram |
|
|
300 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
cas_num |
|
|
310 |
2005-12-08 10:32:33 |
3.5.1.94 |
entry |
glossary |
|
|
338 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
ec_num |
|
1.1.1.289 |
339 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
common_name |
|
sorbose reductase |
340 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
reaction |
|
D-sorbitol + NADP+ = L-sorbose + NADPH + H+ |
341 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
other_names |
|
Sou1p |
342 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
sys_name |
|
D-sorbitol:NADP+ oxidoreductase |
343 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
comments |
|
The reaction occurs predominantly in the reverse direction. This enzyme can also convert fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family. |
344 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
links |
|
|
345 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
class |
|
1 |
346 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
subclass |
|
1 |
347 |
2005-12-08 10:34:59 |
1.1.1.289 |
entry |
subsubclass |
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1 |
348 |
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1.1.1.289 |
entry |
serial |
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289 |
350 |
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1.1.1.289 |
entry |
diagram |
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351 |
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1.1.1.289 |
entry |
cas_num |
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|
361 |
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1.1.1.289 |
entry |
glossary |
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|
594 |
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1.14.13.101 |
entry |
ec_num |
|
1.14.13.101 |
595 |
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1.14.13.101 |
entry |
common_name |
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senecionine N-oxygenase |
596 |
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1.14.13.101 |
entry |
reaction |
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senecionine + NADPH + H+ + O2 = senecionine N-oxide + NADP+ + H2O |
597 |
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1.14.13.101 |
entry |
other_names |
|
senecionine monooxygenase (N-oxide-forming); SNO |
598 |
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1.14.13.101 |
entry |
sys_name |
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senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) |
599 |
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1.14.13.101 |
entry |
comments |
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A flavoprotein. NADH cannot replace NADPH. While pyrrolizidine alkaloids of the senecionine and monocrotaline types are generally good substrates (e.g. senecionine, retrorsine and monocrotaline), the enzyme does not use ester alkaloids lacking an hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-alkaloids (e.g. sarracine) or unesterified necine bases (e.g. senkirkine) as substrates [1]. Senecionine N-oxide is used by insects as a chemical defense: senecionine N-oxide is non-toxic, but it is bioactivated to a toxic form by the action of cytochrome P-450 oxidase when absorbed by insectivores. |
600 |
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1.14.13.101 |
entry |
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