EC 4.2.1.75
uroporphyrinogen-III synthase
Mechanism
Mechanism based on Battersby, A.R., Fookes, C.J.R., Gustafson-Potter, K.E., McDonald, E. and Matcham, G.W.J. Biosynthesis of porphyrins and related macrocycles. Part 18. Proof by spectroscopy and synthesis that unrearranged hydroxymethylbilane is the product from deamination and the substrate for cosynthetase in the biosynthesis of uroporphyrinogen-III J. Chem. Soc., Perkin Trans. 1 (1982) 2427-2444.
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porphyrin biosynthesis (early stages)
EC 4.2.1.75 uroporphyrinogen-III synthase