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Your query returned 4 entries. 
Printable version
| EC | 1.14.14.165 | ||||||||
| Accepted name: | indole-3-carbonyl nitrile 4-hydroxylase | ||||||||
| Reaction: | indole-3-carbonyl nitrile + [reduced NADPH—hemoprotein reductase] + O2 = 4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH—hemoprotein reductase] + H2O | ||||||||
| Glossary: | indole-3-carbonyl nitrile = 2-(1H-indole-3-yl)-2-oxoacetonitrile 4-hydroxyindole-3-carbonyl nitrile = 2-(4-hydroxy-1H-indole-3-yl)-2-oxoacetonitrile |
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| Other name(s): | CYP82C2 | ||||||||
| Systematic name: | indole-3-carbonyl nitrile,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating) | ||||||||
| Comments: | A cytochrome P-450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin [1]. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
| References: |
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| EC | 2.1.1.69 | ||||||||
| Accepted name: | 5-hydroxyfuranocoumarin 5-O-methyltransferase | ||||||||
| Reaction: | (1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction) (2) S-adenosyl-L-methionine + bergaptol = S-adenosyl-L-homocysteine + bergapten |
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| For diagram of reaction, click here | |||||||||
| Glossary: | bergaptol = 5-hydroxypsoralen O-methylbergaptol = bergapten = 5-methoxypsoralen |
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| Other name(s): | furanocoumarin 5-methyltransferase; furanocoumarin 5-O-methyltransferase; bergaptol 5-O-methyltransferase; bergaptol O-methyltransferase; bergaptol methyltransferase; S-adenosyl-L-methionine:bergaptol O-methyltransferase; BMT; S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase | ||||||||
| Systematic name: | S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase | ||||||||
| Comments: | Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin [3], but has little activity on non-coumarin phenols [1]. Caffeate, 5-hydroxyferulate and daphnetin are not substrates [4]. Cu2+, Zn2+ and Co2+ cause enzyme inhibition [4]. (see also EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase) | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 67339-12-2, 101637-31-4 | ||||||||
| References: |
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| EC | 2.1.1.70 | ||||||||
| Accepted name: | 8-hydroxyfuranocoumarin 8-O-methyltransferase | ||||||||
| Reaction: | (1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction) (2) S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin |
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| For diagram of reaction, click here | |||||||||
| Glossary: | xanthotoxin = O-methylxanthotoxol = 8-methoxypsoralen xanthotoxol = 8-hydroxypsoralen |
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| Other name(s): | furanocoumarin 8-methyltransferase; furanocoumarin 8-O-methyl-transferase; xanthotoxol 8-O-methyltransferase; XMT; 8-hydroxyfuranocoumarin 8-O-methyltransferase; SAM:xanthotoxol O-methyltransferase; S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase; xanthotoxol methyltransferase; xanthotoxol O-methyltransferase; S-adenosyl-L-methionine:xanthotoxol O-methyltransferase; S-adenosyl-L-methionine-xanthotoxol O-methyltransferase | ||||||||
| Systematic name: | S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase | ||||||||
| Comments: | Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase). | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 67339-13-3 | ||||||||
| References: |
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| EC | 2.1.1.93 | ||||||||
| Deleted entry: | xanthotoxol O-methyltransferase. Enzyme is identical to EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase | ||||||||