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Your query returned 2 entries. 
Printable version
| EC | 3.5.4.29 | ||
| Accepted name: | GTP cyclohydrolase IIa | ||
| Reaction: | GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate | ||
| For diagram of reaction, click here | |||
| Systematic name: | GTP 8,9-hydrolase (phosphate-forming) | ||
| Comments: | Requires Mg2+. This enzyme catalyses the hydrolysis of the imidazole ring of guanosine 5′-triphosphate, N7-methylguanosine 5′-triphosphate or inosine 5′-triphosphate. Xanthosine 5′-triphosphate and ATP are not substrates. It also catalyses the hydrolysis of diphosphate to form two equivalents of phosphate. Unlike GTP cyclohydrolase II (EC 3.5.4.25), this enzyme does not release formate, but does hydrolyse the diphosphate from GTP to phosphate. | ||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||
| References: |
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| EC | 3.6.1.73 | ||
| Accepted name: | inosine/xanthosine triphosphatase | ||
| Reaction: | (1) inosine 5′-triphosphate + H2O = inosine 5′-diphosphate + phosphate (2) xanthosine 5′-triphosphate + H2O = xanthosine 5′-diphosphate + phosphate |
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| Glossary: | inosine 5′-triphosphate = ITP xanthosine 5′-triphosphate = XTP |
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| Other name(s): | yjjX (gene name) | ||
| Systematic name: | inosine/xanthosine 5′-triphosphate phosphohydrolase | ||
| Comments: | The enzyme, characterized from the bacterium Escherichia coli, preferentially hydrolyses inosine triphosphate and xanthosine triphosphate, which are formed by oxidative deamination damage. By hydrolysing these damaged nucleotides, the enzyme prevents their incorporation into RNA. | ||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||
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