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Your query returned 2 entries. Printable version
EC | 1.14.14.177 | ||
Accepted name: | ultra-long-chain fatty acid ω-hydroxylase | ||
Reaction: | an ultra-long-chain fatty acid + [reduced NADPH—hemoprotein reductase] + O2 = an ultra-long-chain ω-hydroxy fatty acid + [oxidized NADPH—hemoprotein reductase] + H2O | ||
Other name(s): | CYP4F22 (gene name) | ||
Systematic name: | ultra-long-chain fatty acid,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (ω-hydroxylating) | ||
Comments: | The enzyme, which is expressed in the epidermis of mammals, catalyses the ω-hydroxylation of ultra-long-chain fatty acids (C28 to C36). The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
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EC | 2.3.1.296 | ||
Accepted name: | ω-hydroxyceramide transacylase | ||
Reaction: | a linoleate-containing triacyl-sn-glycerol + an ultra-long-chain ω-hydroxyceramide = a diacyl-sn-glycerol + a linoleate-esterified acylceramide | ||
Glossary: | an ultra-long-chain fatty acid = ULCFA = a fatty acid with aliphatic chain of 28 or more carbons an ultra-long-chain ω-hydroxyceramide = a ceramide that contains an ultra-long-chain ω-hydroxyfatty acid moiety (C28-C36) acylceramide = ω-O-acylceramide = a ceramide that contains an ultra-long-chain ω-hydroxyfatty acid moiety (C28-C36) that is further extended by ω-esterification with linoleic acid. |
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Other name(s): | PNPLA1 (gene name) | ||
Systematic name: | triacyl-sn-glycerol:ultra-long-chain ω-hydroxyceramide ω-O-linoleoyltransferase | ||
Comments: | The enzyme participates in the production of acylceramides in the stratum corneum, the outermost layer of the epidermis. Acylceramides are crucial components of the skin permeability barrier. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
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