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Your query returned 2 entries. Printable version
EC | 1.14.13.97 | ||||||||||||
Transferred entry: | taurochenodeoxycholate 6α-hydroxylase. Now EC 1.14.14.57, taurochenodeoxycholate 6α-hydroxylase | ||||||||||||
EC | 1.14.14.57 | ||||||||||||
Accepted name: | taurochenodeoxycholate 6α-hydroxylase | ||||||||||||
Reaction: | (1) taurochenodeoxycholate + [reduced NADPH—hemoprotein reductase] + O2 = taurohyocholate + [oxidized NADPH—hemoprotein reductase] + H2O (2) lithocholate + [reduced NADPH—hemoprotein reductase] + O2 = hyodeoxycholate + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of the biosynthesis of cholic-acid conjugates, click here | |||||||||||||
Glossary: | taurochenodeoxycholic acid = N-(3α,7α-dihydroxy-5β-cholan-24-oyl)taurine taurohyocholic acid = N-(3α,6α,7α-trihydroxy-5β-cholan-24-oyl)taurine hyodeoxycholate = 3α,6α-dihydroxy-5β-cholan-24-oate lithocholate = 3α-hydroxy-5β-cholan-24-oate |
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Other name(s): | CYP3A4; CYP4A21; taurochenodeoxycholate 6α-monooxygenase | ||||||||||||
Systematic name: | taurochenodeoxycholate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6α-hydroxylating) | ||||||||||||
Comments: | A cytochrome P-450 (heme-thiolate) protein. Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid [5]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 105669-85-0 | ||||||||||||
References: |
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