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Your query returned 2 entries. Printable version
EC | 2.1.1.343 | ||||||
Accepted name: | 8-amino-8-demethylriboflavin N,N-dimethyltransferase | ||||||
Reaction: | 2 S-adenosyl-L-methionine + 8-amino-8-demethylriboflavin = 2 S-adenosyl-L-homocysteine + roseoflavin (overall reaction) (1a) S-adenosyl-L-methionine + 8-amino-8-demethylriboflavin = S-adenosyl-L-homocysteine + 8-demethyl-8-(methylamino)riboflavin (1b) S-adenosyl-L-methionine + 8-demethyl-8-(methylamino)riboflavin = S-adenosyl-L-homocysteine + roseoflavin |
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For diagram of roseoflavin biosynthesis, click here | |||||||
Glossary: | roseoflavin = 8-demethyl-8-(dimethylamino)riboflavin | ||||||
Other name(s): | rosA (gene name) | ||||||
Systematic name: | S-adenosyl-L-methionine:8-amino-8-demethylriboflavin N,N-dimethyltransferase | ||||||
Comments: | The enzyme, characterized from the soil bacterium Streptomyces davawensis, catalyses the last two steps in the biosynthesis of the antibiotic roseoflavin. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 2.6.1.114 | ||||||
Accepted name: | 8-demethyl-8-aminoriboflavin-5′-phosphate synthase | ||||||
Reaction: | L-glutamate + FMN + O2 + H2O + 3 acceptor = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5′-phosphate + CO2 + 3 reduced acceptor (overall reaction) (1a) FMN + O2 = 8-demethyl-8-formylriboflavin 5′-phosphate + H2O (1b) 8-demethyl-8-formylriboflavin 5′-phosphate + H2O + acceptor = 8-carboxy-8-demethylriboflavin 5′-phosphate + reduced acceptor (1c) L-glutamate + 8-carboxy-8-demethylriboflavin 5′-phosphate + H2O + 2 acceptor = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5′-phosphate + CO2 + 2 reduced acceptor |
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For diagram of roseoflavin biosynthesis, click here | |||||||
Glossary: | roseoflavin = 8-demethyl-8-(dimethylamino)riboflavin | ||||||
Other name(s): | rosB (gene name) | ||||||
Systematic name: | L-glutamate:FMN aminotransferase (oxidizing, decarboxylating) | ||||||
Comments: | The enzyme, characterized from the bacterium Streptomyces davawensis, has the activities of an oxidoreductase, a decarboxylase, and an aminotransferase. Its combined actions result in the replacement of a methyl substituent of one of the aromatic rings of FMN by an amino group, a step in the biosynthetic pathway of roseoflavin. The reaction requires thiamine for completion. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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