The Enzyme Database

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EC 1.14.13.43     
Accepted name: questin monooxygenase
Reaction: questin + NADPH + H+ + O2 = demethylsulochrin + NADP+
Glossary: questin = 3,8-dihydroxy-1-methoxy-6-methylanthracene-9,10-dione
demethylsulochrin = 2-(2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoic acid
Other name(s): questin oxygenase
Systematic name: questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)
Comments: The enzyme cleaves the anthraquinone ring of questin to form a benzophenone. Involved in the biosynthesis of the seco-anthraquinone (+)-geodin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 115232-45-6
References:
1.  Fujii, I., Ebizuka, Y. and Sankawa, U. A novel anthraquinone ring cleavage enzyme from Aspergillus terreus. J. Biochem. (Tokyo) 103 (1988) 878–883. [PMID: 3182756]
[EC 1.14.13.43 created 1992]
 
 
EC 2.1.1.283     
Accepted name: emodin O-methyltransferase
Reaction: S-adenosyl-L-methionine + emodin = S-adenosyl-L-homocysteine + questin
Glossary: emodin = 1,3,8-trihydroxy-6-methyl-9,10-anthraquinone
questin = 1,6-dihydroxy-8-methoxy-3-methyl-9,10-anthraquinone
Other name(s): EOMT
Systematic name: S-adenosyl-L-methionine:emodin 8-O-methyltransferase
Comments: The enzyme is involved in biosynthesis of the seco-anthraquinone (+)-geodin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Chen, Z.G., Fujii, I., Ebizuka, Y. and Sankawa, U. Emodin O-methyltransferase from Aspergillus terreus. Arch. Microbiol. 158 (1992) 29–34. [PMID: 1444712]
[EC 2.1.1.283 created 2013]
 
 


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