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Your query returned 7 entries. Printable version
EC | 1.4.2.2 | ||||||||||
Accepted name: | nicotine dehydrogenase | ||||||||||
Reaction: | (S)-nicotine + 2 ferricytochrome c = N-methylmyosmine + 2 ferrocytochrome c + 2 H+ | ||||||||||
Glossary: | (S)-nicotine = 3-[(S)-1-methylpyrrolidin-2-yl]pyridine N-methylmyosamine = 3-(1-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridine |
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Other name(s): | nicA2 (gene name) | ||||||||||
Systematic name: | (S)-nicotine:cytochrome c oxidoreductase (N-methylmimosine-forming) | ||||||||||
Comments: | The enzyme, characterized from the bacterium Pseudomonas putida S16, contains an FAD cofactor and belongs to the flavin-containing amine oxidase family. The enzyme from this bacterium is specific for the c-type cytochrome CycN. The product undergoes spontaneous hydrolysis to form pseudooxynicotine. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||
References: |
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EC | 1.4.2.3 | ||||||||||
Accepted name: | pseudooxynicotine dehydrogenase | ||||||||||
Reaction: | pseudooxynicotine + H2O + 2 ferricytochrome c = 4-oxo-4-(pyridin-3-yl)butanal + methylamine + 2 ferrocytochrome c + 2 H+ | ||||||||||
Glossary: | pseudooxynicotine = 4-(methylamino)-1-(pyridin-3-yl)butan-1-one | ||||||||||
Other name(s): | pnaO (gene name) | ||||||||||
Systematic name: | 4-(methylamino)-1-(pyridin-3-yl)butan-1-one:c-type cytochrome oxidoreductase (methylamine releasing) | ||||||||||
Comments: | Contains one non-covalently bound FAD molecule per dimer. This enzyme, characterized from the soil bacteria Pseudomonas sp. HZN6 and Pseudomonas putida S16, is involved in nicotine degradation. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||
References: |
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EC | 1.4.3.24 | ||||||||||
Transferred entry: | pseudooxynicotine oxidase, now classified as EC 1.4.2.3, pseudooxynicotine dehydrogenase | ||||||||||
EC | 1.5.3.5 | ||||||||||
Accepted name: | (S)-6-hydroxynicotine oxidase | ||||||||||
Reaction: | (S)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2 (overall reaction) (1a) (S)-6-hydroxynicotine + O2 = 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O2 (1b) 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one (spontaneous) |
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For diagram of nicotine catabolism by arthrobacter, click here | |||||||||||
Glossary: | (S)-6-hydroxynicotine = 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-2-ol 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one = 6-hydroxypseudooxynicotine 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol = 6-hydroxy-N-methylmyosmine |
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Other name(s): | L-6-hydroxynicotine oxidase; 6-hydroxy-L-nicotine oxidase; 6-hydroxy-L-nicotine:oxygen oxidoreductase; nctB (gene name) | ||||||||||
Systematic name: | (S)-6-hydroxynicotine:oxygen oxidoreductase | ||||||||||
Comments: | A flavoprotein (FAD). The enzyme, which participates in nicotine degradation, is specific for the (S) isomer of 6-hydroxynicotine. The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyses a similar reaction with the less common (R)-isomer (cf. EC 1.5.3.6, (R)-6-hydroxynicotine oxidase). | ||||||||||
Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37256-29-4 | ||||||||||
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EC | 1.5.3.6 | ||||||||||
Accepted name: | (R)-6-hydroxynicotine oxidase | ||||||||||
Reaction: | (R)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2 (overall reaction) (1a) (R)-6-hydroxynicotine + O2 = 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O2 (1b) 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one (spontaneous) |
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For diagram of nicotine catabolism by arthrobacter, click here | |||||||||||
Glossary: | (R)-6-hydroxynicotine = 5-[(2R)-1-methylpyrrolidin-2-yl]pyridin-2-ol 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol = 6-hydroxy-N-methylmyosmine 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one = 6-hydroxypseudooxynicotine |
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Other name(s): | D-6-hydroxynicotine oxidase; 6-hydroxy-D-nicotine oxidase | ||||||||||
Systematic name: | (R)-6-hydroxynicotine:oxygen oxidoreductase | ||||||||||
Comments: | A flavoprotein (FAD). The enzyme, which participates in nicotine degradation, is specific for (R) isomer of 6-hydroxynicotine, derived from the uncommon (R)-nicotine. The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyses a similar reaction with the (S)-isomer (cf. EC 1.5.3.5, (S)-6-hydroxynicotine oxidase). | ||||||||||
Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37233-46-8 | ||||||||||
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EC | 1.5.99.14 | ||||||||||
Accepted name: | 6-hydroxypseudooxynicotine dehydrogenase | ||||||||||
Reaction: | 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H2O = 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor | ||||||||||
For diagram of nicotine catabolism by arthrobacter, click here | |||||||||||
Glossary: | 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one = 6-hydroxypseudooxynicotine 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one = 2,6-dihydroxypseudooxynicotine |
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Systematic name: | 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating) | ||||||||||
Comments: | Contains a cytidylyl molybdenum cofactor [3]. The enzyme, which participates in the nicotine degradation pathway, has been characterized from the soil bacterium Arthrobacter nicotinovorans [1,2]. | ||||||||||
Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
References: |
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EC | 3.7.1.19 | ||||||||||
Accepted name: | 2,6-dihydroxypseudooxynicotine hydrolase | ||||||||||
Reaction: | 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O = 2,6-dihydroxypyridine + 4-methylaminobutanoate | ||||||||||
For diagram of nicotine catabolism by arthrobacter, click here | |||||||||||
Glossary: | 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one = 2,6-dihydroxypseudooxynicotine | ||||||||||
Systematic name: | 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase | ||||||||||
Comments: | The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
References: |
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