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Your query returned 6 entries. 
Printable version
| EC | 1.14.13.184 | ||||
| Transferred entry: | protopanaxadiol 6-hydroxylase. Now EC 1.14.14.121, protopanaxadiol 6-hydroxylase | ||||
| EC | 1.14.14.121 | ||||
| Accepted name: | protopanaxadiol 6-hydroxylase | ||||
| Reaction: | protopanaxadiol + [reduced NADPH—hemoprotein reductase] + O2 = protopanaxatriol + [oxidized NADPH—hemoprotein reductase] + H2O | ||||
| For diagram of dammarenediol II and tirucalla-7,24-dien-3β-ol biosynthesis, click here | |||||
| Glossary: | protopanaxadiol = dammar-24-ene-3β,12β,20-triol protopanaxatriol = dammar-24-ene-3β,6α,12β,20-tetrol |
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| Other name(s): | protopanaxatriol synthase; P6H; CYP716A53v2 | ||||
| Systematic name: | protopanaxadiol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6α-hydroxylating) | ||||
| Comments: | A cytochrome P-450 (heme-thiolate) protein isolated from the rhizomes of ginseng (Panax ginseng). Involved in the biosynthetic pathway of ginsenosides. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
| References: |
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| EC | 2.4.1.363 | ||||
| Accepted name: | ginsenoside 20-O-glucosyltransferase | ||||
| Reaction: | UDP-α-D-glucose + (20S)-protopanaxadiol = UDP + ginsenoside C-K | ||||
| Glossary: | (20S)-protopanaxadiol = (3β,12β)-dammar-24-ene-3,12,20-triol ginsenoside C-K = (3β,12β)-3,12-dihydroxydammar-24-en-20-yl β-D-glucopyranoside |
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| Other name(s): | UGT71A27 (gene name) | ||||
| Systematic name: | UDP-α-D-glucose:(20S)-protopanaxadiol 20-O-glucosyltransferase (configuration-inverting) | ||||
| Comments: | The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the free C20(S)-OH group of dammarane derivative substrates, including protopanaxatriol, dammarenediol II, (20S)-ginsenoside Rh2, and (20S)-ginsenoside Rg3. It does not act on the 20R epimer of protopanaxadiol, or on ginsenosides that are glucosylated at the C-6 position, such as ginsenoside Rh1 or ginsenoside Rg2. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
| References: |
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| EC | 2.4.1.366 | ||||
| Accepted name: | ginsenoside F1 6-O-glucosyltransferase | ||||
| Reaction: | UDP-α-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1 | ||||
| Glossary: | ginsenoside F1 = 3β,6α,12β-trihydroxydammar-24-en-20-yl β-D-glucopyranoside | ||||
| Other name(s): | UGTPg101 (gene name) | ||||
| Systematic name: | UDP-α-D-glucose:ginsenoside F1 6-O-glucosyltransferase | ||||
| Comments: | The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of ginsenoside F1. The enzyme also glucosylates the C-20 position of protopanaxatriol, which forms ginsenoside F1 (cf. EC 2.4.1.363, ginsenoside 20-O-glucosyltransferase). However, unlike EC 2.4.1.367, ginsenoside 6-O-glucosyltransferase, it is not able to glucosylate the C-6 position of protopanaxatriol when position C-20 is not glucosylated. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
| References: |
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| EC | 2.4.1.367 | ||||
| Accepted name: | ginsenoside 6-O-glucosyltransferase | ||||
| Reaction: | (1) UDP-α-D-glucose + protopanaxatriol = UDP + ginsenoside Rh1 (2) UDP-α-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1 |
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| Glossary: | protopanaxatriol = (3β,6α,12β)-dammar-24-ene-3,6,12,20-tetrol ginsenoside F1 = (3β,6α,12β)-trihydroxydammar-24-en-20-yl β-D-glucopyranoside |
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| Other name(s): | UGTPg100 (gene name) | ||||
| Systematic name: | UDP-α-D-glucose:ginsenoside 6-O-glucosyltransferase | ||||
| Comments: | The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of protopanaxatriol and ginsenoside F1. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
| References: |
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| EC | 3.2.1.194 | ||||
| Accepted name: | ginsenosidase type IV | ||||
| Reaction: | a protopanaxatriol-type ginsenoside with two glycosyl residues at position 6 + 2 H2O = a protopanaxatriol-type ginsenoside with no glycosidic modification at position 6 + D-glucopyranose + a monosaccharide (overall reaction) (1a) a protopanaxatriol-type ginsenoside with two glycosyl residues at position 6 + H2O = a protopanaxatriol-type ginsenoside with a single glucosyl at position 6 + a monosaccharide (1b) a protopanaxatriol-type ginsenoside with a single glucosyl at position 6 + H2O = a protopanaxatriol-type ginsenoside with no glycosidic modification at position 6 + D-glucopyranose |
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| For diagram of protopanaxatriol ginsenosides ginsenosidases, click here | |||||
| Glossary: | ginsenoside Re = 20-(β-D-glucopyranosyl)oxy-6α-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyloxy]dammar-24-en-3β,12β-diol ginsenoside Rg1 = 6α,20-bis(β-D-glucopyranosyl)oxy-dammar-24-en-3β,12β-diol ginsenoside F1 = 20-(β-D-glucopyranosyloxy)dammar-24-en-3β,6α,12β-triol |
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| Systematic name: | protopanaxatriol-type ginsenoside 6-β-D-glucohydrolase | ||||
| Comments: | Ginsenosidase type IV catalyses the sequential hydrolysis of the 6-O-β-D-(1→2)-glycosidic bond or the 6-O-α-D-(1→2)-glycosidic bond in protopanaxatriol-type ginsenosides with a disacchride attached to the C6 position, followed by the hydrolysis of the remaining 6-O-β-D-glycosidic bond (e.g. ginsenoside Re → ginsenoside Rg1 → ginsenoside F1). | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
| References: |
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