| EC |
2.3.1.25 |
| Accepted name: |
plasmalogen synthase |
| Reaction: |
acyl-CoA + 1-O-(alk-1-enyl)glycero-3-phosphocholine = CoA + plasmenylcholine |
| Glossary: |
1-O-(alk-1-enyl)glycero-3-phosphocholine = 1-alkenylglycerophosphocholine,
plasmenylcholine = 1-alkenyl-2-acylglycerophosphocholine |
| Other name(s): |
lysoplasmenylcholine acyltransferase; O-1-alkenylglycero-3-phosphorylcholine acyltransferase; 1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase |
| Systematic name: |
acyl-CoA:1-O-(alk-1-enyl)-glycero-3-phosphocholine 2-O-acyltransferase |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37257-10-6 |
| References: |
| 1. |
Waku, K. and Lands, W.E.M. Acyl coenzyme A:1-alkenyl-glycero-3-phosphorylcholine acyltransferase action in plasmalogen biosynthesis. J. Biol. Chem. 243 (1968) 2654–2659. [PMID: 5689955] |
| 2. |
Arthur, G. and Choy, P.C. Acylation of 1-alkenyl-glycerophosphocholine and 1-acyl-glycerophosphocholine in guinea pig heart. Biochem. J. 236 (1986) 481–487. [PMID: 3753462] |
|
| [EC 2.3.1.25 created 1972, modified 2013] |
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| EC |
2.7.8.22 |
| Accepted name: |
1-alkenyl-2-acylglycerol choline phosphotransferase |
| Reaction: |
CDP-choline + 1-alkenyl-2-acylglycerol = CMP + plasmenylcholine |
| Other name(s): |
CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase |
| Systematic name: |
CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 113066-36-7 |
| References: |
| 1. |
Wientzek, M., Man, R.Y.K. and Choy, P.C. Choline glycerophospholipid biosynthesis in the guinea pig heart. Biochem. Cell. Biol. 65 (1987) 860–868. [PMID: 3447597] |
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| [EC 2.7.8.22 created 1990] |
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| EC |
3.3.2.2 |
| Accepted name: |
lysoplasmalogenase |
| Reaction: |
(1) 1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O = an aldehyde + sn-glycero-3-phosphocholine
(2) 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = an aldehyde + sn-glycero-3-phosphoethanolamine |
| Other name(s): |
alkenylglycerophosphocholine hydrolase; alkenylglycerophosphoethanolamine hydrolase; 1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase |
| Systematic name: |
lysoplasmalogen aldehydohydrolase |
| Comments: |
Lysoplasmalogenase is specific for the sn-2-deacylated (lyso) form of plasmalogen and catalyses hydrolytic cleavage of the vinyl ether bond, releasing a fatty aldehyde and sn-glycero-3-phosphocholine or sn-glycero-3-phosphoethanolamine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37288-65-6 |
| References: |
| 1. |
Warner, H.R. and Lands, W.E.M. The metabolism of plasmalogen: enzymatic hydrolysis of the vinyl ether. J. Biol. Chem. 236 (1961) 2404–2409. [PMID: 13783189] |
| 2. |
Ellingson, J.S. and Lands, W.E.M. Phospholipid reactivation of plasmalogen metabolism. Lipids 3 (1968) 111–120. [DOI] [PMID: 17805898] |
| 3. |
Gunawan, J. and Debuch, H. Liberation of free aldehyde from 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine (lysoplasmalogen) by rat liver microsomes. Hoppe-Seyler's Z. Physiol. Chem. 362 (1981) 445–452. [PMID: 7239443] |
| 4. |
Arthur, G., Page, L., Mock, T. and Choy, P.C. The catabolism of plasmenylcholine in the guinea pig heart. Biochem. J. 236 (1986) 475–480. [PMID: 3753461] |
| 5. |
Wu, L.C., Pfeiffer, D.R., Calhoon, E.A., Madiai, F., Marcucci, G., Liu, S. and Jurkowitz, M.S. Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen. J. Biol. Chem. 286 (2011) 24916–24930. [DOI] [PMID: 21515882] |
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| [EC 3.3.2.2 created 1972, modified 1976, (EC 3.3.2.5 created 1984, incorporated 2016), modified 2016] |
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