| EC |
2.3.1.211 |
| Accepted name: |
bisdemethoxycurcumin synthase |
| Reaction: |
2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 |
| Glossary: |
bisdemethoxycurcumin = (1E,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-1,4,6-trien-3-one |
| Other name(s): |
CUS; curcuminoid synthase (ambiguous) |
| Systematic name: |
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming) |
| Comments: |
A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme’s cavity and is not released to the environment. |
| References: |
| 1. |
Morita, H., Wanibuchi, K., Nii, H., Kato, R., Sugio, S. and Abe, I. Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa. Proc. Natl. Acad. Sci. USA 107 (2010) 19778–19783. [PMID: 21041675] |
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| [EC 2.3.1.211 created 2013] |
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| EC |
2.3.1.218 |
| Accepted name: |
phenylpropanoylacetyl-CoA synthase |
| Reaction: |
(1) feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO2 + CoA
(2) 4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA |
| Glossary: |
feruloylacetyl-CoA = feruloyl-diketide-CoA
(4-coumaroyl)acetyl-CoA = 4-coumaroyl-diketide-CoA
phenylpropanoylacetyl-CoA = phenylpropanoyl-diketide-CoA |
| Other name(s): |
phenylpropanoyl-diketide-CoA synthase; DCS |
| Systematic name: |
phenylpropanoyl-CoA:malonyl-CoA phenylpropanoyl-transferase (decarboxylating) |
| Comments: |
The enzyme has been characterized from the plant Curcuma longa (turmeric). It prefers feruloyl-CoA, and has no activity with cinnamoyl-CoA. |
| References: |
| 1. |
Katsuyama, Y., Kita, T., Funa, N. and Horinouchi, S. Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. J. Biol. Chem. 284 (2009) 11160–11170. [PMID: 19258320] |
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| [EC 2.3.1.218 created 2013] |
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