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Your query returned 7 entries. Printable version
EC | 1.3.7.10 | ||||||||||||||||||||
Transferred entry: | pentalenolactone synthase. Now EC 1.14.19.8, pentalenolactone synthase | ||||||||||||||||||||
EC | 1.14.11.36 | ||||||||||||||||||||
Accepted name: | pentalenolactone F synthase | ||||||||||||||||||||
Reaction: | pentalenolactone D + 2 2-oxoglutarate + 2 O2 = pentalenolactone F + 2 succinate + 2 CO2 + H2O (overall reaction) (1a) pentalenolactone D + 2-oxoglutarate + O2 = pentalenolactone E + succinate + CO2 + H2O (1b) pentalenolactone E + 2-oxoglutarate + O2 = pentalenolactone F + succinate + CO2 |
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For diagram of pentalenolactone biosynthesis, click here | |||||||||||||||||||||
Glossary: | pentalenolactone D = (1S,4aR,6aS,9aR)-1,8,8-trimethyl-2-oxo-1,2,4,4a,6a,7,8,9-octahydropentaleno[1,6a-c]pyran-5-carboxylate pentalenolactone E = (4aR,6aS,9aR)-8,8-dimethyl-1-methylene-2-oxo-1,2,4,4a,6a,7,8,9-octahydropentaleno[1,6a-c]pyran-5-carboxylate pentalenolactone F = (1′R,4′aR,6′aS,9′aR)-8′,8′-dimethyl-2′-oxo-4′,4′a,6′a,8′,9′-hexahydrospiro[oxirane-2,1′-pentaleno[1,6a-c]pyran]-5′-carboxylic acid |
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Other name(s): | penD (gene name); pntD (gene name); ptlD (gene name) | ||||||||||||||||||||
Systematic name: | pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase | ||||||||||||||||||||
Comments: | Requires iron(II) and ascorbate. Isolated from the bacteria Streptomyces exfoliatus, Streptomyces arenae and Streptomyces avermitilis. Part of the pentalenolactone biosynthesis pathway. | ||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||||||
References: |
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EC | 1.14.11.81 | ||||||||||||||||||||
Accepted name: | (–)-cyclopenine synthase | ||||||||||||||||||||
Reaction: | (1) cyclopeptine + 2-oxoglutarate + O2 = dehydrocyclopeptine + succinate + CO2 + H2O (2) dehydrocyclopeptine + 2-oxoglutarate + O2 = (–)-cyclopenine + succinate + CO2 |
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For diagram of cyclopeptine, cyclopenine and viridicatin biosynthesis, click here | |||||||||||||||||||||
Glossary: | cyclopeptine = (3S)-3-benzyl-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (–)-cyclopenine = (3S,3′R)-4-methyl-3′-phenyl-1H-spiro[1,4-benzodiazepine-3,2′-oxirane]-2,5-dione |
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Other name(s): | asqJ (gene name) | ||||||||||||||||||||
Systematic name: | cyclopeptine,2-oxoglutarate:oxygen oxidoreductase ((–)-cyclopenine-forming) | ||||||||||||||||||||
Comments: | This fungal enzyme is involved in the biosynthesis of quinolone compounds. it catalyses two oxidation reactions: the first reaction results in a desaturation; the second reaction is a monooxygenation of the double bond, forming an epoxide. The enzyme is also active with 4′-methoxycyclopeptine. | ||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||||||
References: |
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EC | 1.14.14.11 | ||||||||||||||||||||
Accepted name: | styrene monooxygenase | ||||||||||||||||||||
Reaction: | styrene + FADH2 + O2 = (S)-2-phenyloxirane + FAD + H2O | ||||||||||||||||||||
Other name(s): | StyA; SMO; NSMOA | ||||||||||||||||||||
Systematic name: | styrene,FADH2:oxygen oxidoreductase | ||||||||||||||||||||
Comments: | The enzyme catalyses the first step in the aerobic styrene degradation pathway. It forms a two-component system with a reductase (StyB) that utilizes NADH to reduce flavin-adenine dinucleotide, which is then transferred to the oxygenase. | ||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||||||
References: |
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EC | 1.14.19.8 | ||||||||||||||||||||
Accepted name: | pentalenolactone synthase | ||||||||||||||||||||
Reaction: | pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ = pentalenolactone + 2 oxidized ferredoxin + 2 H2O | ||||||||||||||||||||
For diagram of pentalenolactone biosynthesis, click here | |||||||||||||||||||||
Glossary: | pentalenolactone F = (1R,4aR,6aS,9aR)-8,8-dimethyl-2-oxo-4,4a,6a,8,9-hexahydrospiro[oxirane-2,1-pentaleno[1,6a-c]pyran]-5-carboxylic acid pentalenolactone = (1R,4aR,6aR,7S,9aS)-7,8-dimethyl-2-oxo-4,4a,6a,7-tetrahydrospiro[oxirane-2,1-pentaleno[1,6a-c]pyran]-5-carboxylic acid |
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Other name(s): | penM (gene name); pntM (gene name) | ||||||||||||||||||||
Systematic name: | pentalenolactone-reduced-ferredoxin:oxygen oxidoreductase (pentalenolactone-forming) | ||||||||||||||||||||
Comments: | A heme-thiolate protein (P-450). Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. | ||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||||||||
References: |
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EC | 3.3.2.9 | ||||||||||||||||||||
Accepted name: | microsomal epoxide hydrolase | ||||||||||||||||||||
Reaction: | (1) cis-stilbene oxide + H2O = (1R,2R)-1,2-diphenylethane-1,2-diol (2) 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol |
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Glossary: | oxirane = ethylene oxide = a 3-membered oxygen-containing ring oxetane = 1,3-propylene oxide = a 4-membered oxygen-containing ring |
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Other name(s): | microsomal oxirane/oxetane hydrolase; epoxide hydratase (ambiguous); microsomal epoxide hydratase (ambiguous); epoxide hydrase; microsomal epoxide hydrase; arene-oxide hydratase (ambiguous); benzo[a]pyrene-4,5-oxide hydratase; benzo(a)pyrene-4,5-epoxide hydratase; aryl epoxide hydrase (ambiguous); cis-epoxide hydrolase; mEH; EPHX1 (gene name) | ||||||||||||||||||||
Systematic name: | cis-stilbene-oxide hydrolase | ||||||||||||||||||||
Comments: | This is a key hepatic enzyme that catalyses the hydrolytic ring opening of oxiranes (epoxides) and oxetanes to give the corresponding diols. The enzyme is involved in the metabolism of numerous substrates including the stereoselective hydrolytic ring opening of 7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to the corresponding trans-dihydrodiols. The reaction proceeds via a triad mechanism and involves the formation of an hydroxyalkyl-enzyme intermediate. Five epoxide-hydrolase enzymes have been identified in vertebrates to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase). | ||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||||||||
References: |
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EC | 4.1.99.27 | ||||||||||||||||||||
Accepted name: | cyclopenase | ||||||||||||||||||||
Reaction: | (–)-cyclopenine = viridicatin + methyl isocyanate | ||||||||||||||||||||
For diagram of cyclopeptine, cyclopenine and viridicatin biosynthesis, click here | |||||||||||||||||||||
Glossary: | (–)-cyclopenine = (3S,3′R)-4-methyl-3′-phenyl-1H-spiro[1,4-benzodiazepine-3,2′-oxirane]-2,5-dione viridicatin = 3-hydroxy-4-phenyl-1H-quinolin-2-one |
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Other name(s): | asqI (gene name) | ||||||||||||||||||||
Systematic name: | (–)-cyclopenine methyl-isocyanate lyase (viridicatin-forming) | ||||||||||||||||||||
Comments: | This fungal enzyme catalyses a key reaction in the biosynthesis of quinolone compounds, converting the benzodiazepine structure into a quinolone structure. The enzyme is also active with (–)-4′-methoxycyclopenine. | ||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||||||
References: |
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