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Your query returned 2 entries. Printable version
EC | 1.14.18.11 | ||||||||
Accepted name: | plant 4α-monomethylsterol monooxygenase | ||||||||
Reaction: | 24-methylidenelophenol + 6 ferrocytochrome b5 + 3 O2 + 6 H+ = 3β-hydroxyergosta-7,24(241)-dien-4α-carboxylate + 6 ferricytochrome b5 + 4 H2O (overall reaction) (1a) 24-methylidenelophenol + 2 ferrocytochrome b5 + O2 + 2 H+ = 4α-(hydroxymethyl)ergosta-7,24(241)-dien-3β-ol + 2 ferricytochrome b5 + H2O (1b) 4α-(hydroxymethyl)ergosta-7,24(241)-dien-3β-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 4α-formylergosta-7,24(241)-dien-3β-ol + 2 ferricytochrome b5 + 2 H2O (1c) 4α-formylergosta-7,24(241)-dien-3β-ol + 2 ferrocytochrome b5 + O2 + 2 H+ = 3β-hydroxyergosta-7,24(241)-dien-4α-carboxylate + 2 ferricytochrome b5 + H2O |
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Glossary: | 24-methylidenelophenol = 4α-methyl-5α-ergosta-7,24-dien-3β-ol | ||||||||
Other name(s): | SMO2 (gene name) | ||||||||
Systematic name: | 24-ethylidenelophenol,ferrocytochrome-b5:oxygen oxidoreductase (C-4α-methyl-hydroxylating) | ||||||||
Comments: | This plant enzyme catalyses a step in the biosynthesis of sterols. It acts on the methyl group of the 4α-methylated intermediates 24-ethylidenelophenol and 24-methylidenelophenol and catalyses three successive oxidations, turning it into a carboxyl group. The carboxylate is subsequently removed by EC 1.1.1.418, plant 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating). Unlike the fungal/animal enzyme EC 1.14.18.9, 4α-methylsterol monooxygenase, this enzyme is not able to act on 4,4-dimethylated substrates. That activity, which occurs earlier in the pathway, is performed in plants by a second enzyme, EC 1.14.18.10, plant 4,4-dimethylsterol C-4α-methyl-monooxygenase. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
References: |
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EC | 2.1.1.143 | ||||||||
Accepted name: | 24-methylenesterol C-methyltransferase | ||||||||
Reaction: | S-adenosyl-L-methionine + 24-methylenelophenol = S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol | ||||||||
For diagram of sterol-sidechain modification, click here | |||||||||
Glossary: | lophenol = 4α-methyl-5α-cholesta-7-en-3β-ol | ||||||||
Other name(s): | SMT2; 24-methylenelophenol C-241-methyltransferase | ||||||||
Systematic name: | S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase | ||||||||
Comments: | This is the second methylation step of plant sterol biosynthesis (cf EC 2.1.1.142, cycloartenol 24-C-methyltransferase). | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 67165-89-3 | ||||||||
References: |
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