EC |
1.14.14.85 |
Accepted name: |
7-deoxyloganate 7-hydroxylase |
Reaction: |
7-deoxyloganate + [reduced NADPH—hemoprotein reductase] + O2 = loganate + [oxidized NADPH—hemoprotein reductase] + H2O |
|
For diagram of secologanin biosynthesis, click here |
Glossary: |
logonate = (1S,4aS,6S,7R,7aS)-1-(β-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate |
Other name(s): |
CYP72A224 (gene name); 7-deoxyloganin 7-hydroxylase (incorrect); 7-deoxyloganin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (7α-hydroxylating) (incorrect) |
Systematic name: |
7-deoxyloganate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (7α-hydroxylating) |
Comments: |
The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme-thiolate) enzyme. It catalyses a reaction in the pathway leading to biosynthesis of monoterpenoid indole alkaloids. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 335305-40-3 |
References: |
1. |
Katano, N., Yamamoto, H., Iio, R. and Inoue, K. 7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures. Phytochemistry 58 (2001) 53–58. [DOI] [PMID: 11524113] |
2. |
Miettinen, K., Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., van der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K.M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J. and Werck-Reichhart, D. The seco-iridoid pathway from Catharanthus roseus. Nat. Commun. 5:3606 (2014). [PMID: 24710322] |
|
[EC 1.14.14.85 created 2002 as EC 1.14.13.74, transferred 2018 to EC 1.14.14.85, modified 2018] |
|
|
|
|