The Enzyme Database

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EC 1.1.1.416     
Accepted name: isopyridoxal dehydrogenase (5-pyridoxolactone-forming)
Reaction: isopyridoxal + NAD+ = 5-pyridoxolactone + NADH + H+
Glossary: isopyridoxal = 5-hydroxy-4-(hydroxymethyl)-6-methylpyridine-3-carbaldehyde
5-pyridoxolactone = 7-hydroxy-6-methylfuro[3,4-c]pyridin-3(1H)-one
Systematic name: isopyridoxal:NAD+ oxidoreductase (5-pyridoxolactone-forming)
Comments: The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.2.1.102, isopyridoxal dehydrogenase (5-pyridoxate-forming).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Lee, Y.C., Nelson, M.J. and Snell, E.E. Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. J. Biol. Chem. 261 (1986) 15106–15111. [PMID: 3533936]
[EC 1.1.1.416 created 2018]
 
 
EC 1.1.3.12     
Accepted name: pyridoxine 4-oxidase
Reaction: pyridoxine + O2 = pyridoxal + H2O2
Other name(s): pyridoxin 4-oxidase; pyridoxol 4-oxidase
Systematic name: pyridoxine:oxygen 4-oxidoreductase
Comments: A flavoprotein. Can also use 2,6-dichloroindophenol as an acceptor.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37250-82-1
References:
1.  Sundaram, T.K. and Snell, E.E. The bacterial oxidation of vitamin B6. V. The enzymatic formation of pyridoxal and isopyridoxal from pyridoxine. J. Biol. Chem. 244 (1969) 2577–2584. [PMID: 5769992]
[EC 1.1.3.12 created 1972, modified 1976]
 
 
EC 1.1.99.9     
Accepted name: pyridoxine 5-dehydrogenase
Reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor
Other name(s): pyridoxal-5-dehydrogenase; pyridoxol 5-dehydrogenase; pyridoxin 5-dehydrogenase; pyridoxine dehydrogenase; pyridoxine 5′-dehydrogenase; pyridoxine:(acceptor) 5-oxidoreductase
Systematic name: pyridoxine:acceptor 5-oxidoreductase
Comments: A flavoprotein (FAD).
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 9023-39-6
References:
1.  Sundaram, T.K. and Snell, E.E. The bacterial oxidation of vitamin B6. V. The enzymatic formation of pyridoxal and isopyridoxal from pyridoxine. J. Biol. Chem. 244 (1969) 2577–2584. [PMID: 5769992]
[EC 1.1.99.9 created 1972, modified 1976]
 
 
EC 1.2.1.100     
Accepted name: 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase
Reaction: 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD+ + H2O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+
For diagram of pyridoxal catabolism, click here
Other name(s): mlr6793 (locus name)
Systematic name: 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate:NAD+ 5-oxidoreductase
Comments: The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
References:
1.  Lee, Y.C., Nelson, M.J. and Snell, E.E. Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. J. Biol. Chem. 261 (1986) 15106–15111. [PMID: 3533936]
2.  Yokochi, N., Yoshikane, Y., Matsumoto, S., Fujisawa, M., Ohnishi, K. and Yagi, T. Gene identification and characterization of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD+-dependent dismutase. J. Biochem. 145 (2009) 493–503. [DOI] [PMID: 19218190]
3.  Mugo, A.N., Kobayashi, J., Mikami, B., Yoshikane, Y., Yagi, T. and Ohnishi, K. Crystal structure of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD(+)-dependent dismutase from Mesorhizobium loti. Biochem. Biophys. Res. Commun. 456 (2015) 35–40. [DOI] [PMID: 25446130]
[EC 1.2.1.100 created 2018]
 
 
EC 1.2.1.102     
Accepted name: isopyridoxal dehydrogenase (5-pyridoxate-forming)
Reaction: isopyridoxal + NAD+ + H2O = 5-pyridoxate + NADH + H+
Glossary: isopyridoxal = 5-hydroxy-4-(hydroxymethyl)-6-methylpyridine-3-carbaldehyde
5-pyridoxate = 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate
Systematic name: isopyridoxal:NAD+ oxidoreductase (5-pyridoxate-forming)
Comments: The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.1.1.416, isopyridoxal dehydrogenase (5-pyridoxolactone-forming).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Lee, Y.C., Nelson, M.J. and Snell, E.E. Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. J. Biol. Chem. 261 (1986) 15106–15111. [PMID: 3533936]
[EC 1.2.1.102 created 2018]
 
 


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