EC	1.1.1.313
Accepted name:	sulfoacetaldehyde reductase
Reaction:	isethionate + NADP+ = 2-sulfoacetaldehyde + NADPH + H+
Glossary:	isethionate = 2-hydroxyethanesulfonate 2-sulfoacetaldehyde = 2-oxoethanesulfonate
Other name(s):	isfD (gene name)
Systematic name:	isethionate:NADP+ oxidoreductase
Comments:	Catalyses the reaction only in the opposite direction. Involved in taurine degradation. The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyse this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells.
References:	1.  Krejcik, Z., Hollemeyer, K., Smits, T.H. and Cook, A.M. Isethionate formation from taurine in Chromohalobacter salexigens: purification of sulfoacetaldehyde reductase. Microbiology 156 (2010) 1547–1555. [PMID: 20133363]
[EC 1.1.1.313 created 2011]
EC	4.4.1.38
Accepted name:	isethionate sulfite-lyase
Reaction:	isethionate = acetaldehyde + sulfite
Glossary:	isethionate = 2-hydroxyethanesulfonate
Other name(s):	islA (gene name)
Systematic name:	isethionate sulfite-lyase
Comments:	The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, participates in a taurine degradation pathway that leads to sulfide production. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster.
References:	1.  Peck, S.C., Denger, K., Burrichter, A., Irwin, S.M., Balskus, E.P. and Schleheck, D. A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia. Proc. Natl. Acad. Sci. USA 116 (2019) 3171–3176. [PMID: 30718429] 2.  Xing, M., Wei, Y., Zhou, Y., Zhang, J., Lin, L., Hu, Y., Hua, G.,, N. Nanjaraj Urs, A., Liu, D., Wang, F., Guo, C., Tong, Y., Li, M., Liu, Y., Ang, E.L., Zhao, H., Yuchi, Z. and Zhang, Y. Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria. Nat. Commun. 10:1609 (2019). [PMID: 30962433]
[EC 4.4.1.38 created 2021]