|
Your query returned 14 entries. Printable version
EC | 2.4.1.250 | ||||||||
Accepted name: | D-inositol-3-phosphate glycosyltransferase | ||||||||
Reaction: | UDP-N-acetyl-α-D-glucosamine + 1D-myo-inositol 3-phosphate = 1-O-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP | ||||||||
For diagram of mycothiol biosynthesis, click here | |||||||||
Glossary: | mycothiol = 1-O-[2-(N2-acetyl-L-cysteinamido)-2-deoxy-α-D-glucopyranosyl]-1D-myo-inositol | ||||||||
Other name(s): | mycothiol glycosyltransferases; MshA; UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate α-D-glycosyltransferase | ||||||||
Systematic name: | UDP-N-acetyl-α-D-glucosamine:1D-myo-inositol 3-phosphate α-D-glycosyltransferase (configuration-retaining) | ||||||||
Comments: | The enzyme, which belongs to the GT-B fold superfamily, catalyses the first dedicated reaction in the biosynthesis of mycothiol [1]. The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate [2]. A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate [3]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
References: |
| ||||||||
EC | 2.7.1.64 | ||||||||
Accepted name: | inositol 3-kinase | ||||||||
Reaction: | ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate | ||||||||
Other name(s): | inositol-1-kinase (phosphorylating); myoinositol kinase; myo-inositol 1-kinase | ||||||||
Systematic name: | ATP:myo-inositol 1-phosphotransferase | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37278-07-2 | ||||||||
References: |
| ||||||||
EC | 2.7.1.68 | ||||||||
Accepted name: | 1-phosphatidylinositol-4-phosphate 5-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 |
||||||||
Other name(s): | diphosphoinositide kinase; PIP kinase; phosphatidylinositol 4-phosphate kinase; phosphatidylinositol-4-phosphate 5-kinase; type I PIP kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase | ||||||||
Comments: | This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 104645-76-3 | ||||||||
References: |
| ||||||||
EC | 2.7.1.137 | ||||||||
Accepted name: | phosphatidylinositol 3-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P |
||||||||
Other name(s): | 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase | ||||||||
Comments: | One mammalian isoform is known. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 115926-52-8 | ||||||||
References: |
| ||||||||
EC | 2.7.1.150 | ||||||||
Accepted name: | 1-phosphatidylinositol-3-phosphate 5-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2 |
||||||||
Other name(s): | type III PIP kinase; phosphatidylinositol 3-phosphate 5-kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
References: |
| ||||||||
EC | 2.7.1.153 | ||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 3-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
||||||||
Other name(s): | type I phosphoinositide 3-kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase | ||||||||
Comments: | This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 103843-30-7 | ||||||||
References: |
| ||||||||
EC | 2.7.1.154 | ||||||||
Accepted name: | phosphatidylinositol-4-phosphate 3-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 |
||||||||
Other name(s): | type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase | ||||||||
Comments: | This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 141176-94-5 | ||||||||
References: |
| ||||||||
EC | 2.7.7.74 | ||||||||
Accepted name: | 1L-myo-inositol 1-phosphate cytidylyltransferase | ||||||||
Reaction: | CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol | ||||||||
For diagram of bis(1L-myo-inositol) 1,3′-phosphate biosynthesis, click here | |||||||||
Glossary: | 1L-myo-inositol 1-phosphate = 1D-myo-inositol 3-phosphate | ||||||||
Other name(s): | CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)); IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)); L-myo-inositol-1-phosphate cytidylyltransferase | ||||||||
Systematic name: | CTP:1L-myo-inositol 1-phosphate cytidylyltransferase | ||||||||
Comments: | In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3′-phosphate, a widespread organic solute in microorganisms adapted to hot environments. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
References: |
| ||||||||
EC | 2.7.8.34 | ||||||||
Accepted name: | CDP-L-myo-inositol myo-inositolphosphotransferase | ||||||||
Reaction: | CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate = CMP + bis(1L-myo-inositol) 3,1′-phosphate 1-phosphate | ||||||||
For diagram of bis(1L-myo-inositol) 1,3′-phosphate biosynthesis, click here | |||||||||
Glossary: | 1L-myo-inositol 1-phosphate = 1D-myo-inositol 3-phosphate | ||||||||
Other name(s): | CDP-inositol:inositol-1-phosphate transferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)); DIPPS (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)) | ||||||||
Systematic name: | CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase | ||||||||
Comments: | In many organisms this activity is catalysed by a bifunctional enzyme. The di-myo-inositol-1,3′-phosphate-1′-phosphate synthase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-1L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3-phosphate, a widespread organic solute in microorganisms adapted to hot environments. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
References: |
| ||||||||
EC | 2.7.8.39 | ||||||||
Accepted name: | archaetidylinositol phosphate synthase | ||||||||
Reaction: | CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate = CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate | ||||||||
Glossary: | 1L-myo-inositol 1-phosphate = 1D-myo-inositol 3-phosphate CDP-2,3-bis-(O-phytanyl)-sn-glycerol = CDP-2,3-di-(O-phytanyl)-sn-glycerol = CDP-archaeol 1-archaetidyl-1D-myo-inositol 3-phosphate = archaetidyl-myo-inositol 1-phosphate |
||||||||
Other name(s): | AIP synthase | ||||||||
Systematic name: | CDP-2,3-bis-(O-phytanyl)-sn-glycerol:1L-myo-inositol 1-phosphate 1-sn-archaetidyltransferase | ||||||||
Comments: | Requires Mg2+ or Mn2+ for activity. The enzyme is involved in biosynthesis of archaetidyl-myo-inositol, a compound essential for glycolipid biosynthesis in archaea. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
References: |
| ||||||||
EC | 3.1.3.64 | ||||||||
Accepted name: | phosphatidylinositol-3-phosphatase | ||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | inositol 1-phosphate = Ins-1-P inositol 1,3-bisphosphate = Ins(1,3)P2 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P |
||||||||
Other name(s): | inositol-1,3-bisphosphate 3-phosphatase; inositol 1,3-bisphosphate phosphatase; inositol-polyphosphate 3-phosphatase; D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase; phosphatidyl-3-phosphate 3-phosphohydrolase | ||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase | ||||||||
Comments: | This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3)P2 to Ins-1-P. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 124248-47-1 | ||||||||
References: |
| ||||||||
EC | 3.1.3.66 | ||||||||
Accepted name: | phosphatidylinositol-3,4-bisphosphate 4-phosphatase | ||||||||
Reaction: | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | inositol 3-phosphate = Ins-3-P inositol 1,3-bisphosphate = Ins(1,3)P2 inositol 3,4-bisphosphate = Ins(3,4)P2 inositol 1,3,4-trisphosphate = Ins(1,3,4)P3 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P |
||||||||
Other name(s): | inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II | ||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase | ||||||||
Comments: | Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 123644-80-4 | ||||||||
References: |
| ||||||||
EC | 3.1.3.78 | ||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 4-phosphatase | ||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | ||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 5-phosphate = PtdIns5P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
||||||||
Other name(s): | phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 4-Ptase; IpgD; PtdIns-4,5-P2 4-phosphatase type I; PtdIns-4,5-P2 4-phosphatase type II; type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase; type 1 4-phosphatase | ||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | ||||||||
Comments: | Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
References: |
| ||||||||
EC | 5.5.1.4 | ||||||||
Accepted name: | inositol-3-phosphate synthase | ||||||||
Reaction: | D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate | ||||||||
For diagram of myo-inositol biosynthesis, click here and for mechanism of reaction, click here | |||||||||
Other name(s): | myo-inositol-1-phosphate synthase; D-glucose 6-phosphate cycloaldolase; inositol 1-phosphate synthatase; glucose 6-phosphate cyclase; inositol 1-phosphate synthetase; glucose-6-phosphate inositol monophosphate cycloaldolase; glucocycloaldolase; 1L-myo-inositol-1-phosphate lyase (isomerizing) | ||||||||
Systematic name: | 1D-myo-inositol-3-phosphate lyase (isomerizing) | ||||||||
Comments: | Requires NAD+, which dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9032-95-5 | ||||||||
References: |
| ||||||||