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Your query returned 5 entries. 
Printable version
| EC | 1.14.19.69 | ||||||
| Accepted name: | biflaviolin synthase | ||||||
| Reaction: | (1) 2 flaviolin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 3,3′-biflaviolin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O (2) 2 flaviolin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 3,8′-biflaviolin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O |
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| For diagram of flaviolin metabolism, click here | |||||||
| Glossary: | flaviolin = 4,5,7-trihydroxynaphthalene-1,2-dione 3,3′-biflaviolin = 3,3′,6,6′,8,8′-hexahydroxy-2,2′-binaphthalene-1,1′,4,4′-tetraone 3,8′-biflaviolin = 2,3′,4,6′,7,8′-hexahydroxy-1,2′-binaphthalene-1′,4′,5,8-tetraone |
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| Other name(s): | CYP158A2 (gene name); cytochrome P450 158A2 | ||||||
| Systematic name: | flaviolin,reduced ferredoxin:oxygen oxidoreductase | ||||||
| Comments: | This cytochrome-P-450 (heme-thiolate) enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses a phenol oxidation C-C coupling reaction, which results in the polymerization of flaviolin to form biflaviolin or triflaviolin without the incorporation of oxygen into the product [1,3]. The products are highly conjugated pigments that protect the bacterium from the deleterious effects of UV irradiation [1]. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
| References: |
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| EC | 1.14.21.7 | ||||||
| Transferred entry: | biflaviolin synthase. Now EC 1.14.19.69, biflaviolin synthase | ||||||
| EC | 2.5.1.123 | ||||||
| Accepted name: | flaviolin linalyltransferase | ||||||
| Reaction: | geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate | ||||||
| For diagram of flaviolin metabolism, click here | |||||||
| Glossary: | flaviolin = 2,5,7-trihydroxynaphthalene-1,4-dione 3-linalylflaviolin = 2,5,7-trihydroxy-3-(3,7-dimethylocta-1,6-dien-3-yl)naphthalene-1,4-dione |
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| Other name(s): | Fnq26 | ||||||
| Systematic name: | geranyl-diphosphate:flaviolin 3-linalyltransferase | ||||||
| Comments: | Does not require Mg2+ or any other metal ions. Isolated from the bacterium Streptomyces cinnamonensis. In vitro the enzyme also forms traces of 3-geranylflaviolin. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
| References: |
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| EC | 2.5.1.124 | ||||||
| Accepted name: | 6-linalyl-2-O,3-dimethylflaviolin synthase | ||||||
| Reaction: | geranyl diphosphate + 2-O,3-dimethylflaviolin = diphosphate + 6-linalyl-2-O,3-dimethylflaviolin | ||||||
| Glossary: | flaviolin = 2,5,7-trihydroxy-1,4-naphthoquinone 2-O,3-dimethylflaviolin = 5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione 6-linalyl-2-O,3-dimethylflaviolin = 6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione |
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| Other name(s): | Fur7; 6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase | ||||||
| Systematic name: | geranyl-diphosphate:2-O-methyl-3-methylflaviolin geranyltransferase (6-linalyl-2-O,3-dimethylflaviolin-forming) | ||||||
| Comments: | The enzyme is involved in biosynthesis of the polyketide-isoprenoid furaquinocin D in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 6-linalyl-2-O,3-dimethylflaviolin and 7-O-geranyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.125, 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase) in a 10:1 ratio. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
| References: |
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| EC | 2.5.1.125 | ||||||
| Accepted name: | 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase | ||||||
| Reaction: | geranyl diphosphate + 2-O,3-dimethylflaviolin = diphosphate + 7-O-geranyl-2-O,3-dimethylflaviolin | ||||||
| Glossary: | flaviolin = 2,5,7-trihydroxy-1,4-naphthoquinone 2-O,3-dimethylflaviolin = 5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione 7-O-geranyl-2-O,3-dimethylflaviolin = 7-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione |
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| Other name(s): | Fur7 | ||||||
| Systematic name: | geranyl-diphosphate:2-O,3-dimethylflaviolin geranyltransferase (7-O-geranyl-2-O,3-dimethylflaviolin-forming) | ||||||
| Comments: | The enzyme is involved in furaquinocin biosynthesis in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 7-O-geranyl-2-O,3-dimethylflaviolin and 6-linalyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.124, 6-linalyl-2-O,3-dimethylflaviolin synthase) in a 1:10 ratio. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
| References: |
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