| EC |
1.1.1.216 |
| Accepted name: |
farnesol dehydrogenase (NADP+) |
| Reaction: |
(2E,6E)-farnesol + NADP+ = (2E,6E)-farnesal + NADPH + H+ |
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For diagram of juvenile hormone biosynthesis, click here |
| Other name(s): |
NADP+-farnesol dehydrogenase; farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase |
| Systematic name: |
(2E,6E)-farnesol:NADP+ 1-oxidoreductase |
| Comments: |
Also acts, more slowly, on (2Z,6E)-farnesol, geraniol, citronerol and nerol. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 89089-75-8, 90804-55-0 |
| References: |
| 1. |
Inoue, H., Tsuji, H. and Uritani, I. Characterization and activity change of farnesol dehydrogenase in black rot fungus-infected sweet-potato. Agric. Biol. Chem. 48 (1984) 733–738. |
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| [EC 1.1.1.216 created 1989] |
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| EC |
1.1.1.354 |
| Accepted name: |
farnesol dehydrogenase (NAD+) |
| Reaction: |
(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+ |
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For diagram of juvenile hormone biosynthesis, click here |
| Other name(s): |
NAD+-farnesol dehydrogenase |
| Systematic name: |
(2E,6E)-farnesol:NAD+ 1-oxidoreductase |
| Comments: |
The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Noge, K., Kato, M., Mori, N., Kataoka, M., Tanaka, C., Yamasue, Y., Nishida, R. and Kuwahara, Y. Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae). FEBS J. 275 (2008) 2807–2817. [DOI] [PMID: 18422649] |
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| [EC 1.1.1.354 created 2013] |
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| EC |
1.2.1.94 |
| Accepted name: |
farnesal dehydrogenase |
| Reaction: |
(2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+ |
|
For diagram of juvenile hormone biosynthesis, click here |
| Glossary: |
farnesal = 3,7,11-trimethyldodeca-2,6,10-trienal
farnesoate = 3,7,11-trimethyldodeca-2,6,10-trienoate |
| Other name(s): |
AaALDH3 |
| Systematic name: |
farnesal:NAD+ oxidoreductase |
| Comments: |
Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (dengue mosquito). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Madhavan, K., Conscience-Egli, M., Sieber, F. and Ursprung, H. Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase. J. Insect Physiol. 19 (1973) 235–241. [DOI] [PMID: 4631837] |
| 2. |
Baker, F.C., Mauchamp, B., Tsai, L.W. and Schooley, D.A. Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta. J. Lipid Res. 24 (1983) 1586–1594. [PMID: 6366103] |
| 3. |
Rivera-Perez, C., Nouzova, M., Clifton, M.E., Garcia, E.M., LeBlanc, E. and Noriega, F.G. Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes. Insect Biochem. Mol. Biol. 43 (2013) 675–682. [DOI] [PMID: 23639754] |
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| [EC 1.2.1.94 created 2015] |
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| EC |
1.8.3.6 |
| Accepted name: |
farnesylcysteine lyase |
| Reaction: |
S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2 |
| Other name(s): |
FC lyase; FCLY |
| Systematic name: |
S-(2E,6E)-farnesyl-L-cysteine oxidase |
| Comments: |
A flavoprotein (FAD). In contrast to mammalian EC 1.8.3.5 (prenylcysteine oxidase) the farnesylcysteine lyase from Arabidopsis is specific for S-farnesyl-L-cysteine and shows no activity with S-geranylgeranyl-L-cysteine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Huizinga, D.H., Denton, R., Koehler, K.G., Tomasello, A., Wood, L., Sen, S.E. and Crowell, D.N. Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis. Mol Plant 3 (2010) 143–155. [DOI] [PMID: 19969520] |
| 2. |
Crowell, D.N., Huizinga, D.H., Deem, A.K., Trobaugh, C., Denton, R. and Sen, S.E. Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. Plant J. 50 (2007) 839–847. [DOI] [PMID: 17425716] |
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| [EC 1.8.3.6 created 2011] |
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