The Enzyme Database

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Accepted name: farnesol dehydrogenase (NADP+)
Reaction: (2E,6E)-farnesol + NADP+ = (2E,6E)-farnesal + NADPH + H+
For diagram of juvenile hormone biosynthesis, click here
Other name(s): NADP+-farnesol dehydrogenase; farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase
Systematic name: (2E,6E)-farnesol:NADP+ 1-oxidoreductase
Comments: Also acts, more slowly, on (2Z,6E)-farnesol, geraniol, citronerol and nerol.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 89089-75-8, 90804-55-0
1.  Inoue, H., Tsuji, H. and Uritani, I. Characterization and activity change of farnesol dehydrogenase in black rot fungus-infected sweet-potato. Agric. Biol. Chem. 48 (1984) 733–738.
[EC created 1989]
Accepted name: farnesol dehydrogenase (NAD+)
Reaction: (2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+
For diagram of juvenile hormone biosynthesis, click here
Other name(s): NAD+-farnesol dehydrogenase
Systematic name: (2E,6E)-farnesol:NAD+ 1-oxidoreductase
Comments: The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC, geraniol dehydrogenase (NAD+)]. Unlike EC, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Noge, K., Kato, M., Mori, N., Kataoka, M., Tanaka, C., Yamasue, Y., Nishida, R. and Kuwahara, Y. Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae). FEBS J. 275 (2008) 2807–2817. [DOI] [PMID: 18422649]
[EC created 2013]
Accepted name: farnesal dehydrogenase
Reaction: (2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+
For diagram of juvenile hormone biosynthesis, click here
Glossary: farnesal = 3,7,11-trimethyldodeca-2,6,10-trienal
farnesoate = 3,7,11-trimethyldodeca-2,6,10-trienoate
Other name(s): AaALDH3
Systematic name: farnesal:NAD+ oxidoreductase
Comments: Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (dengue mosquito).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Madhavan, K., Conscience-Egli, M., Sieber, F. and Ursprung, H. Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase. J. Insect Physiol. 19 (1973) 235–241. [DOI] [PMID: 4631837]
2.  Baker, F.C., Mauchamp, B., Tsai, L.W. and Schooley, D.A. Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta. J. Lipid Res. 24 (1983) 1586–1594. [PMID: 6366103]
3.  Rivera-Perez, C., Nouzova, M., Clifton, M.E., Garcia, E.M., LeBlanc, E. and Noriega, F.G. Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes. Insect Biochem. Mol. Biol. 43 (2013) 675–682. [DOI] [PMID: 23639754]
[EC created 2015]
Accepted name: farnesylcysteine lyase
Reaction: S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2
Other name(s): FC lyase; FCLY
Systematic name: S-(2E,6E)-farnesyl-L-cysteine oxidase
Comments: A flavoprotein (FAD). In contrast to mammalian EC (prenylcysteine oxidase) the farnesylcysteine lyase from Arabidopsis is specific for S-farnesyl-L-cysteine and shows no activity with S-geranylgeranyl-L-cysteine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Huizinga, D.H., Denton, R., Koehler, K.G., Tomasello, A., Wood, L., Sen, S.E. and Crowell, D.N. Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis. Mol Plant 3 (2010) 143–155. [DOI] [PMID: 19969520]
2.  Crowell, D.N., Huizinga, D.H., Deem, A.K., Trobaugh, C., Denton, R. and Sen, S.E. Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine. Plant J. 50 (2007) 839–847. [DOI] [PMID: 17425716]
[EC created 2011]

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