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Your query returned 17 entries. Printable version
EC | 1.17.1.2 | ||||||||||||||||
Transferred entry: | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, now classified as EC 1.17.7.4, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase. | ||||||||||||||||
EC | 2.5.1.8 | ||||||||||||||||
Transferred entry: | tRNA isopentenyltransferase. As it is now known that the substrate is dimethylallyl diphosphate, the enzyme has been transferred to EC 2.5.1.75, tRNA dimethylallyltransferase | ||||||||||||||||
EC | 2.5.1.10 | ||||||||||||||||
Accepted name: | (2E,6E)-farnesyl diphosphate synthase | ||||||||||||||||
Reaction: | geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate | ||||||||||||||||
For diagram of terpenoid biosynthesis, click here | |||||||||||||||||
Other name(s): | farnesyl-diphosphate synthase; geranyl transferase I; prenyltransferase; farnesyl pyrophosphate synthetase; farnesylpyrophosphate synthetase; geranyltranstransferase | ||||||||||||||||
Systematic name: | geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase | ||||||||||||||||
Comments: | Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37277-79-5 | ||||||||||||||||
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EC | 2.5.1.11 | ||||||||||||||||
Transferred entry: | trans-octaprenyltranstransferase. Now covered by EC 2.5.1.84 (all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]) and EC 2.5.1.85 (all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]) | ||||||||||||||||
EC | 2.5.1.29 | ||||||||||||||||
Accepted name: | geranylgeranyl diphosphate synthase | ||||||||||||||||
Reaction: | (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate | ||||||||||||||||
For diagram of terpenoid biosynthesis, click here | |||||||||||||||||
Other name(s): | geranylgeranyl-diphosphate synthase; geranylgeranyl pyrophosphate synthetase; geranylgeranyl-PP synthetase; farnesyltransferase; geranylgeranyl pyrophosphate synthase; farnesyltranstransferase (obsolete) | ||||||||||||||||
Systematic name: | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase | ||||||||||||||||
Comments: | Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9032-58-0 | ||||||||||||||||
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EC | 2.5.1.34 | ||||||||||||||||
Accepted name: | 4-dimethylallyltryptophan synthase | ||||||||||||||||
Reaction: | prenyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-en-1-yl)-L-tryptophan | ||||||||||||||||
For diagram of ergot alkaloid biosynthesis, click here | |||||||||||||||||
Glossary: | prenyl diphosphate = dimethylallyl diphosphate | ||||||||||||||||
Other name(s): | dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase; dimethylallyltryptophan synthetase; dimethylallylpyrophosphate:tryptophan dimethylallyl transferase; DMAT synthetase; 4-(γ,gamma-dimethylallyl)tryptophan synthase; tryptophan dimethylallyltransferase; dimethylallyl-diphosphate:L-tryptophan 4-dimethylallyltransferase | ||||||||||||||||
Systematic name: | prenyl-diphosphate:L-tryptophan 4-prenyltransferase | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 55127-01-0 | ||||||||||||||||
References: |
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EC | 2.5.1.75 | ||||||||||||||||
Accepted name: | tRNA dimethylallyltransferase | ||||||||||||||||
Reaction: | prenyl diphosphate + adenosine37 in tRNA = diphosphate + N6-(3-methylbut-2-en-1-yl)-adenosine37 in tRNA | ||||||||||||||||
For diagram of N6-(Dimethylallyl)adenosine37 modified tRNA biosynthesis, click here | |||||||||||||||||
Glossary: | N6-(3-methylbut-2-en-1-yl)-adenine37 in tRNA = N6-dimethylallyladenine37 in tRNA | ||||||||||||||||
Other name(s): | tRNA prenyltransferase; MiaA; transfer ribonucleate isopentenyltransferase (incorrect); Δ2-isopentenyl pyrophosphate:tRNA-Δ2-isopentenyl transferase (incorrect); Δ2-isopentenyl pyrophosphate:transfer ribonucleic acid Δ2-isopentenyltransferase (incorrect); dimethylallyl-diphosphate: tRNA dimethylallyltransferase; dimethylallyl-diphosphate:adenine37 in tRNA dimethylallyltransferase | ||||||||||||||||
Systematic name: | prenyl-diphosphate:adenine37 in tRNA prenyltransferase | ||||||||||||||||
Comments: | Formerly known as tRNA isopentenyltransferase, but it is now known that prenyl diphosphate, rather than isopentenyl diphosphate, is the substrate. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||||
References: |
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EC | 2.5.1.92 | ||||||||||||||||
Accepted name: | (2Z,6Z)-farnesyl diphosphate synthase | ||||||||||||||||
Reaction: | prenyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate (1a) prenyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate (1b) neryl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6Z)-farnesyl diphosphate |
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For diagram of all-cis-polyprenyl diphosphate, click here | |||||||||||||||||
Glossary: | prenyl diphosphate = dimethylallyl diphosphate | ||||||||||||||||
Other name(s): | cis,cis-farnesyl diphosphate synthase; Z,Z-FPP synthase; zFPS; Z,Z-farnesyl pyrophosphate synthase; dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units) | ||||||||||||||||
Systematic name: | prenyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units) | ||||||||||||||||
Comments: | This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphate synthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphate synthase]. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||||
References: |
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EC | 2.5.1.107 | ||||||||||||||||
Accepted name: | verruculogen prenyltransferase | ||||||||||||||||
Reaction: | prenyl diphosphate + verruculogen = diphosphate + fumitremorgin A | ||||||||||||||||
For diagram of fumitremorgin alkaloid biosynthesis (part 2), click here | |||||||||||||||||
Glossary: | prenyl diphosphate = dimethylallyl diphosphate verruculogen = (5R,10S,10aR,14aS,15bS)-10,10a-dihydroxy-6-methoxy-2,2-dimethyl-5-(2-methylprop-1-en-1-yl)-1,10,10a,14,14a,15b-hexahydro-12H-3,4-dioxa-5a,11a,15a-triazacycloocta[1,2,3-lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione fumitremorgin A = (5R,10S,10aR,14aS,15bS)-10a-hydroxy-7-methoxy-2,2-dimethyl-10-[(3-methylbut-2-en-1-yl)oxy]-5-(2-methylprop-1-en-1-yl)-1,10,10a,14,14a,15b-hexahydro-12H-3,4-dioxa-5a,11a,15a-triazacycloocta[1,2,3-lm]indeno[5,6-b]fluorene-11,15(H,13H)-dione |
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Other name(s): | FtmPT3; dimethylallyl-diphosphate:verruculogen dimethylallyl-O-transferase | ||||||||||||||||
Systematic name: | prenyl-diphosphate:verruculogen dimethylallyl-O-transferase | ||||||||||||||||
Comments: | Found in a number of fungi. Catalyses the last step in the biosynthetic pathway of the indole alkaloid fumitremorgin A. The enzyme from the fungus Neosartorya fischeri is also active with fumitremorgin B and 12α,13α-dihydroxyfumitremorgin C. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||
References: |
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EC | 2.5.1.111 | ||||||||||||||||
Accepted name: | 4-hydroxyphenylpyruvate 3-dimethylallyltransferase | ||||||||||||||||
Reaction: | prenyl diphosphate + 3-(4-hydroxyphenyl)pyruvate = diphosphate + 3-(4-hydroxy-3-prenylphenyl)pyruvate | ||||||||||||||||
For diagram of 3-dimethylallyl-4-hydroxybenzoate biosynthesis, click here and for diagram of 4-hydroxyphenylpyruvate metabolites, click here | |||||||||||||||||
Glossary: | 3-dimethylallyl-4-hydroxyphenylpyruvate = 3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-2-oxopropanoate | ||||||||||||||||
Other name(s): | CloQ; 4HPP dimethylallyltransferase; NovQ; dimethylallyl diphosphate:4-hydroxyphenylpyruvate 3-dimethylallyltransferase | ||||||||||||||||
Systematic name: | prenyl-diphosphate:3-(4-hydroxyphenyl)pyruvate 3′-prenyltransferase | ||||||||||||||||
Comments: | The enzyme's product feeds into the biosynthesis of the aminocoumarin antibiotics clorobiocin and novobiocin [1]. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||||
References: |
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EC | 2.5.1.112 | ||||||||||||||||
Accepted name: | adenylate dimethylallyltransferase (ADP/ATP-dependent) | ||||||||||||||||
Reaction: | (1) prenyl diphosphate + ADP = diphosphate + N6-prenyladenosine 5′-diphosphate (2) prenyl diphosphate + ATP = diphosphate + N6-prenyladenosine 5′-triphosphate |
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For diagram of N6-(Dimethylallyl)adenosine phosphates biosynthesis, click here | |||||||||||||||||
Other name(s): | cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:ADP/ATP Δ2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); dimethylallyl diphosphate:ATP/ADP isopentenyltransferase: IPT; dimethylallyl-diphosphate:ADP/ATP dimethylallyltransferase | ||||||||||||||||
Systematic name: | prenyl-diphosphate:ADP/ATP prenyltransferase | ||||||||||||||||
Comments: | Involved in the biosynthesis of cytokinins in plants. The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP [1]. Other isoforms, such as IPT1 from Arabidopsis thaliana [1,2] and the enzyme from the common hop, Humulus lupulus [3], also have a lower activity with AMP (cf. EC 2.5.1.27, adenylate dimethylallyltransferase). | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||||
References: |
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EC | 2.5.1.121 | ||||||||||||||||
Accepted name: | 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase | ||||||||||||||||
Reaction: | prenyl diphosphate + 5,10-dihydrophenazine-1-carboxylate = diphosphate + 9-prenyl-5,10-dihydrophenazine-1-carboxylate | ||||||||||||||||
Glossary: | 9-prenyl-5,10-dihydrophenazine-1-carboxylate = 9-(3-methylbut-2-en-1-yl)-5,10-dihydrophenazine-1-carboxylate | ||||||||||||||||
Other name(s): | PpzP; dihydrophenazine-1-carboxylate dimethylallyltransferase; 5,10-dihydrophenazine 1-carboxylate dimethylallyltransferase; dimethylallyl diphosphate:5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase | ||||||||||||||||
Systematic name: | prenyl-diphosphate:5,10-dihydrophenazine-1-carboxylate 9-prenyltransferase | ||||||||||||||||
Comments: | The enzyme is involved in the biosynthesis of prenylated phenazines by the bacterium Streptomyces anulatus. It is specific for both prenyl diphosphate and 5,10-dihydrophenazine-1-carboxylate. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||
References: |
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EC | 2.5.1.122 | ||||||||||||||||
Accepted name: | 4-O-dimethylallyl-L-tyrosine synthase | ||||||||||||||||
Reaction: | prenyl diphosphate + L-tyrosine = diphosphate + 4-O-prenyl-L-tyrosine | ||||||||||||||||
Other name(s): | SirD; dimethylallyl diphosphate:L-tyrosine 4-O-dimethylallyltransferase | ||||||||||||||||
Systematic name: | prenyl-diphosphate:L-tyrosine 4-O-prenyltransferase | ||||||||||||||||
Comments: | The enzyme is involved in biosynthesis of the phytotoxin sirodesmin PL by the phytopathogenic ascomycete Leptosphaeria maculans. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||
References: |
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EC | 2.5.1.158 | ||||||||||||||||
Accepted name: | hexaprenyl diphosphate synthase (prenyl-diphosphate specific) | ||||||||||||||||
Reaction: | prenyl diphosphate + 5 3-methylbut-3-en-1-yl diphosphate = all-trans-hexaprenyl diphosphate + 5 diphosphate | ||||||||||||||||
Glossary: | prenyl diphosphate = dimethylallyl diphosphate 3-methylbut-3-en-1-yl diphosphate = isopentenyl diphosphate |
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Other name(s): | HexPPS | ||||||||||||||||
Systematic name: | prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate transferase (adding 5 units of 3-methylbut-3-en-1-yl) | ||||||||||||||||
Comments: | This activity has been characterized from a number of fungal bifunctional enzymes. Following the formation of hexaprenyl diphosphate, a different domain in the enzymes catalyses its cyclization into a triterpene (see EC 4.2.3.221, macrophomene synthase and EC 4.2.3.220, talaropentaene synthase). cf. EC 2.5.1.82, hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||||
References: |
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EC | 2.5.1.159 | ||||||||||||||||
Accepted name: | hapalindole G dimethylallyltransferase | ||||||||||||||||
Reaction: | (1) prenyl diphosphate + hapalindole G = ambiguine A + diphosphate (2) prenyl diphosphate + hapalindole U = ambiguine H + diphosphate |
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For diagram of hapalindole/fischerindole biosynthesis, click here | |||||||||||||||||
Glossary: | prenyl diphosphate = dimethylallyl diphosphate hapalindole G = (6aS,8R,9R,10R,10aS)-8-chloro-10-isocyano-6,6,9-trimethyl-9-vinyl-2,6,6a,7,8,9,10,10a-octahydronaphtho[1,2,3-cd]indole ambiguine A = (6aS,8R,9R,10R,10aS)-8-chloro-10-isocyano-6,6,9-trimethyl-1-(2-methylbut-3-en-2-yl)-9-vinyl-2,6,6a,7,8,9,10,10a-octahydronaphtho[1,2,3-cd]indole hapalindole U = (6aS,9R,10R,10aS)-10-isocyano-6,6,9-trimethyl-9-vinyl-2,6,6a,7,8,9,10,10a-octahydronaphtho[1,2,3-cd]indole ambiguine H = (6aS,9R,10R,10aS)-9-ethenyl-10-isocyano-6,6,9-trimethyl-1-(2-methylbut-3-en-2-yl)-2,6,6a,7,8,9,10,10a-octahydronaphtho[1,2,3-cd]indole |
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Other name(s): | ambP3 (gene name); famD1 (gene name) | ||||||||||||||||
Systematic name: | prenyl-diphosphate:hapalindole G prenyltransferase (ambiguine A-forming) | ||||||||||||||||
Comments: | Requires Mg2+. The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, is involved in the biosynthesis of hapalindole-type alkaloids. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||
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EC | 3.6.1.76 | ||||||||||||||||
Accepted name: | prenyl-diphosphate phosphatase | ||||||||||||||||
Reaction: | (1) prenyl diphosphate + H2O = prenyl phosphate + phosphate (2) 3-methylbut-3-en-1-yl diphosphate + H2O = 3-methylbut-3-en-1-yl phosphate + phosphate |
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Glossary: | isopentenyl = 3-methylbut-3-en-1-yl prenyl = 3-methylbut-2-en-1-yl = dimethylallyl dimethylallyl diphosphate = DMAPP isopentenyl diphosphate = IPP |
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Systematic name: | prenyl diphosphate/3-methylbut-3-en-1-yl diphosphate phosphohydrolase | ||||||||||||||||
Comments: | The enzyme, characterized from the methanogenic archaeon Methanosarcina mazei, belongs to the Nudix hydrolase family (a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to a moiety). Its main purpose is to provide the substrate for EC 2.5.1.129, flavin prenyltransferase. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||
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EC | 4.2.3.27 | ||||||||||||||||
Accepted name: | isoprene synthase | ||||||||||||||||
Reaction: | prenyl diphosphate = isoprene + diphosphate | ||||||||||||||||
For diagram of isoprene biosynthesis and metabolism, click here | |||||||||||||||||
Glossary: | isoprene = 2-methylbuta-1,3-diene | ||||||||||||||||
Other name(s): | ISPC; ISPS; dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) | ||||||||||||||||
Systematic name: | prenyl-diphosphate diphosphate-lyase (isoprene-forming) | ||||||||||||||||
Comments: | Requires Mg2+ or Mn2+ for activity. This enzyme is located in the chloroplast of isoprene-emitting plants, such as poplar and aspen, and may be activitated by light-dependent changes in chloroplast pH and Mg2+ concentration [2,8]. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 139172-14-8 | ||||||||||||||||
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