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Your query returned 5 entries. Printable version
EC | 1.3.1.107 | ||||
Accepted name: | sanguinarine reductase | ||||
Reaction: | (1) dihydrosanguinarine + NAD(P)+ = sanguinarine + NAD(P)H + H+ (2) dihydrochelirubine + NAD(P)+ = chelirubine + NAD(P)H + H+ |
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For diagram of chelirubine, macarpine and sanguinarine biosynthesis, click here | |||||
Glossary: | sanguinarine = 13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4′,5′:4,5]benzo[1,2-c]phenanthridinium dihydrosanguinarine = 13-methyl-13,14-dihydro-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4′,5′:4,5]benzo[1,2-c]phenanthridine chelirubine = 5-methoxy-13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4′,5′:4,5]benzo[1,2-c]phenanthridinium dihydrochelirubine = 5-methoxy-13-methyl-13,14-dihydro-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4′,5′:4,5]benzo[1,2-c]phenanthridinium |
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Systematic name: | dihydrosanguinarine:NAD(P)+ oxidoreductase | ||||
Comments: | The enzyme, purified from the California poppy (Eschscholzia californica), is involved in detoxifying the phytoalexin sanguinarine produced by poppy itself (cf. EC 1.5.3.12, dihydrobenzophenanthridine oxidase), when it binds to the cell wall of the poppy cell. The reaction with NADPH is up to three times faster than that with NADH at low concentrations (<10 uM) of the dinucleotide. At higher concentrations the reaction with NADPH is inhibited but not that with NADH [1]. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 1.5.3.12 | ||||
Accepted name: | dihydrobenzophenanthridine oxidase | ||||
Reaction: | (1) dihydrosanguinarine + O2 = sanguinarine + H2O2 (2) dihydrochelirubine + O2 = chelirubine + H2O2 (3) dihydromacarpine + O2 = macarpine + H2O2 |
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For diagram of chelirubine, macarpine and sanguinarine biosynthesis, click here | |||||
Systematic name: | dihydrobenzophenanthridine:oxygen oxidoreductase | ||||
Comments: | A CuII enzyme found in higher plants that produces oxidized forms of the benzophenanthridine alkaloids | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 114051-83-1 | ||||
References: |
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EC | 1.14.13.56 | ||||
Transferred entry: | dihydrosanguinarine 10-monooxygenase. Now EC 1.14.14.100, dihydrosanguinarine 10-monooxygenase | ||||
EC | 1.14.14.100 | ||||
Accepted name: | dihydrosanguinarine 10-monooxygenase | ||||
Reaction: | dihydrosanguinarine + [reduced NADPH—hemoprotein reductase] + O2 = 10-hydroxydihydrosanguinarine + [oxidized NADPH—hemoprotein reductase] + H2O | ||||
For diagram of chelirubine, macarpine and sanguinarine biosynthesis, click here | |||||
Other name(s): | dihydrosanguinarine 10-hydroxylase | ||||
Systematic name: | dihydrosanguinarine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating) | ||||
Comments: | A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 144388-41-0 | ||||
References: |
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EC | 2.1.1.119 | ||||
Accepted name: | 10-hydroxydihydrosanguinarine 10-O-methyltransferase | ||||
Reaction: | S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine = S-adenosyl-L-homocysteine + dihydrochelirubine | ||||
For diagram of chelirubine, macarpine and sanguinarine biosynthesis, click here | |||||
Systematic name: | S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase | ||||
Comments: | This reaction is part of the pathway for synthesis of benzophenanthridine alkaloids in plants. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 144388-39-6 | ||||
References: |
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