EC |
2.4.1.310 |
Accepted name: |
vancomycin aglycone glucosyltransferase |
Reaction: |
UDP-α-D-glucose + vancomycin aglycone = UDP + devancosaminyl-vancomycin |
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For diagram of chloroorienticin biosynthesis, click here |
Glossary: |
devancosaminyl-vancomycin = vancomycin pseudoaglycone |
Other name(s): |
GtfB (ambiguous) |
Systematic name: |
UDP-α-D-glucose:vancomycin aglycone 48-O-β-glucosyltransferase |
Comments: |
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Losey, H.C., Peczuh, M.W., Chen, Z., Eggert, U.S., Dong, S.D., Pelczer, I., Kahne, D. and Walsh, C.T. Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry 40 (2001) 4745–4755. [DOI] [PMID: 11294642] |
2. |
Mulichak, A.M., Losey, H.C., Walsh, C.T. and Garavito, R.M. Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics. Structure 9 (2001) 547–557. [DOI] [PMID: 11470430] |
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[EC 2.4.1.310 created 2013] |
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EC |
2.4.1.322 |
Accepted name: |
devancosaminyl-vancomycin vancosaminetransferase |
Reaction: |
dTDP-β-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin |
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For diagram of chloroorienticin biosynthesis, click here |
Glossary: |
dTDP-β-L-vancosamine = dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-β-L-lyxo-hexopyranose |
Other name(s): |
devancosaminyl-vancomycin TDP-vancosaminyltransferase; GtfD; dTDP-β-L-vancomycin:desvancosaminyl-vancomycin β-L-vancosaminetransferase; desvancosaminyl-vancomycin vancosaminetransferase |
Systematic name: |
dTDP-β-L-vancomycin:devancosaminyl-vancomycin β-L-vancosaminetransferase |
Comments: |
The enzyme, isolated from the bacterium Amycolatopsis orientalis, catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Losey, H.C., Peczuh, M.W., Chen, Z., Eggert, U.S., Dong, S.D., Pelczer, I., Kahne, D. and Walsh, C.T. Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry 40 (2001) 4745–4755. [DOI] [PMID: 11294642] |
2. |
Mulichak, A.M., Lu, W., Losey, H.C., Walsh, C.T. and Garavito, R.M. Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. Biochemistry 43 (2004) 5170–5180. [DOI] [PMID: 15122882] |
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[EC 2.4.1.322 created 2014] |
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