|
Your query returned 3 entries. Printable version
EC | 2.1.1.102 | ||
Accepted name: | demethylmacrocin O-methyltransferase | ||
Reaction: | S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin | ||
For diagram of tylosin biosynthesis, click here | |||
Other name(s): | demethylmacrocin methyltransferase; DMOMT | ||
Systematic name: | S-adenosyl-L-methionine:demethylmacrocin 2′′′-O-methyltransferase | ||
Comments: | Requires Mg2+. The enzyme, isolated from the bacterium Streptomyces fradiae, is involved in the biosynthesis of the macrolide antibiotic tylosin. The 2-hydroxy group of a 6-deoxy-D-allose moiety in demethylmacrocin acts as the methyl acceptor. Also acts on demethyllactenocin, giving lactenocin. Not identical with EC 2.1.1.101 macrocin O-methyltransferase. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 120313-64-6 | ||
References: |
| ||
EC | 2.4.1.317 | ||
Accepted name: | O-mycaminosyltylonolide 6-deoxyallosyltransferase | ||
Reaction: | 5-O-β-D-mycaminosyltylonolide + dTDP-6-deoxy-α-D-allose = dTDP + demethyllactenocin | ||
For diagram of tylosin biosynthesis, click here | |||
Glossary: | mycaminose = 3,6-dideoxy-3-dimethylamino-glucopyranose tylonolide = 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-16-ethyl-4,6-dihydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-dien-7-yl]acetaldehyde demethyllactenocin = [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-β-D-allopyranoside |
||
Other name(s): | tylN (gene name) | ||
Systematic name: | dTDP-6-deoxy-α-D-allose:5-O-β-D-mycaminosyltylonolide 23-O-6-deoxy-α-D-allosyltransferase | ||
Comments: | The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
| ||
EC | 2.4.1.318 | ||
Accepted name: | demethyllactenocin mycarosyltransferase | ||
Reaction: | dTDP-β-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin | ||
For diagram of tylosin biosynthesis, click here | |||
Glossary: | dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose demethyllactenocin = [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside |
||
Other name(s): | tylCV (gene name); tylC5 (gene name) | ||
Systematic name: | dTDP-β-L-mycarose:demethyllactenocin 4′-O-α-L-mycarosyltransferase | ||
Comments: | The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
| ||