EC |
2.4.1.318 |
Accepted name: |
demethyllactenocin mycarosyltransferase |
Reaction: |
dTDP-β-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin |
Glossary: |
dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose
demethyllactenocin = [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside |
Other name(s): |
tylCV (gene name); tylC5 (gene name) |
Systematic name: |
dTDP-β-L-mycarose:demethyllactenocin 4′-O-α-L-mycarosyltransferase |
Comments: |
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. |
References: |
1. |
Bate, N., Butler, A.R., Smith, I.P. and Cundliffe, E. The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. Microbiology 146 (2000) 139–146. [PMID: 10658660] |
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[EC 2.4.1.318 created 2014] |
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EC |
2.4.1.328 |
Accepted name: |
erythronolide mycarosyltransferase |
Reaction: |
dTDP-β-L-mycarose + erythronolide B = dTDP + 3-α-L-mycarosylerythronolide B |
Glossary: |
dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose
L-mycarose = 2,6-dideoxy-3-C-methyl-L-ribo-hexose |
Other name(s): |
EryBV |
Systematic name: |
dTDP-β-L-mycarose:erythronolide B L-mycarosyltransferase |
Comments: |
Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin. |
References: |
1. |
Zhang, C., Fu, Q., Albermann, C., Li, L. and Thorson, J.S. The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification. ChemBioChem 8 (2007) 385–390. [PMID: 17262863] |
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[EC 2.4.1.328 created 2014] |
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