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Your query returned 9 entries. Printable version
EC | 1.3.3.16 | ||||||||
Accepted name: | oxazoline dehydrogenase | ||||||||
Reaction: | (1) a [protein]-(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline + O2 = a [protein]-(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole + H2O2 (2) a [protein]-(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline + O2 = a [protein]-(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole + H2O2 (3) a [protein]-(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline + O2 = a [protein]-(S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole + H2O2 |
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Other name(s): | azoline oxidase; thiazoline oxidase; cyanobactin oxidase; patG (gene name); mcaG (gene name); artG (gene name); lynG (gene name); tenG (gene name) | ||||||||
Systematic name: | a [protein]-2-oxazoline:oxygen oxidoreductase (2-oxazole-forming) | ||||||||
Comments: | Contains FMN. This enzyme oxidizes 2-oxazoline, 5-methyl-2-oxazoline, and 2-thiazoline within peptides, which were formed by EC 6.2.2.2, oxazoline synthase, and EC 6.2.2.3, thiazoline synthase, to the respective pyrrole-type rings. The enzyme is found as either a stand-alone protein or as a domain within a multifunctional protein (the G protein) that also functions as a peptidase. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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EC | 1.13.11.84 | ||||||||
Accepted name: | crocetin dialdehyde synthase | ||||||||
Reaction: | zeaxanthin + 2 O2 = crocetin dialdehyde + 2 3β-hydroxy-β-cyclocitral (overall reaction) (1a) zeaxanthin + O2 = 3β-hydroxy-8′-apo-β-carotenal + 3β-hydroxy-β-cyclocitral (1b) 3β-hydroxy-8′-apo-β-carotenal + O2 = crocetin dialdehyde + 3β-hydroxy-β-cyclocitral |
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Glossary: | crocetin dialdehyde = 8,8′-diapocarotene-8,8′-dial zeaxanthin = (3R,3′R)-β,β-carotene-3,3′-diol 3β-hydroxy-β-cyclocitral = (4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-carboxaldehyde |
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Other name(s): | CCD2; zeaxanthin 7,8-dioxygenase | ||||||||
Systematic name: | zeaxanthin:oxygen 7′,8′-oxidoreductase (bond-cleaving) | ||||||||
Comments: | The enzyme, characterized from the plant Crocus sativus (saffron), acts twice, cleaving 3β-hydroxy-β-cyclocitral off each 3-hydroxy end group. It is part of the zeaxanthin degradation pathway in that plant, leading to the different compounds that impart the color, flavor and aroma of the saffron spice. The enzyme can similarly cleave the 7-8 double bond of other carotenoids with a 3-hydroxy-β-carotenoid end group. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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EC | 1.14.13.196 | ||||||||
Accepted name: | L-ornithine N5-monooxygenase [NAD(P)H] | ||||||||
Reaction: | L-ornithine + NAD(P)H + H+ + O2 = N5-hydroxy-L-ornithine + NAD(P)+ + H2O | ||||||||
Other name(s): | SidA (ambiguous) | ||||||||
Systematic name: | L-ornithine,NAD(P)H:oxygen oxidoreductase (N5-hydroxylating) | ||||||||
Comments: | A flavoprotein (FAD). The enzyme from the pathogenic fungus Aspergillus fumigatus catalyses a step in the biosynthesis of the siderophores triacetylfusarinine and desferriferricrocin, while the enzyme from the bacterium Kutzneria sp. 744 is involved in the biosynthesis of piperazate, a building block of the kutzneride family of antifungal antibiotics. Activity of the fungal enzyme is higher with NADPH, due to the fact that following the reduction of the flavin, NADP+ (but not NAD+) stabilizes the C4a-hydroperoxyflavin intermediate that oxidizes the substrate [3]. cf. EC 1.14.13.195, L-ornithine N5-monooxygenase (NADPH). | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
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EC | 1.14.99.42 | ||||||||
Transferred entry: | zeaxanthin 7,8-dioxygenase. Now EC 1.13.11.84, crocetin dialdehyde synthase | ||||||||
EC | 2.1.1.101 | ||||||||
Accepted name: | macrocin O-methyltransferase | ||||||||
Reaction: | S-adenosyl-L-methionine + macrocin = S-adenosyl-L-homocysteine + tylosin | ||||||||
For diagram of tylosin biosynthesis, click here | |||||||||
Other name(s): | macrocin methyltransferase; S-adenosyl-L-methionine-macrocin O-methyltransferase; MOMT (ambiguous); tylF (gene name) | ||||||||
Systematic name: | S-adenosyl-L-methionine:macrocin 3′′′-O-methyltransferase | ||||||||
Comments: | Requires Mg2+, Mn2+ or Co2+. The 3-hydroxy group of the 2-O-methyl-6-deoxy-D-allose moiety in the macrolide antibiotic macrosin acts as methyl acceptor, generating tylosin, another macrolide antibiotic. Isolated from the bacterium Streptomyces fradiae. Not identical with EC 2.1.1.102, demethylmacrocin O-methyltransferase. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 79468-52-3 | ||||||||
References: |
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EC | 2.1.1.102 | ||||||||
Accepted name: | demethylmacrocin O-methyltransferase | ||||||||
Reaction: | S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin | ||||||||
For diagram of tylosin biosynthesis, click here | |||||||||
Other name(s): | demethylmacrocin methyltransferase; DMOMT | ||||||||
Systematic name: | S-adenosyl-L-methionine:demethylmacrocin 2′′′-O-methyltransferase | ||||||||
Comments: | Requires Mg2+. The enzyme, isolated from the bacterium Streptomyces fradiae, is involved in the biosynthesis of the macrolide antibiotic tylosin. The 2-hydroxy group of a 6-deoxy-D-allose moiety in demethylmacrocin acts as the methyl acceptor. Also acts on demethyllactenocin, giving lactenocin. Not identical with EC 2.1.1.101 macrocin O-methyltransferase. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 120313-64-6 | ||||||||
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EC | 2.4.1.271 | ||||||||
Accepted name: | crocetin glucosyltransferase | ||||||||
Reaction: | (1) UDP-α-D-glucose + crocetin = UDP + β-D-glucosyl crocetin (2) UDP-α-D-glucose + β-D-glucosyl crocetin = UDP + bis(β-D-glucosyl) crocetin (3) UDP-α-D-glucose + β-D-gentiobiosyl crocetin = UDP + β-D-gentiobiosyl β-D-glucosyl crocetin |
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For diagram of crocin biosynthesis, click here | |||||||||
Other name(s): | crocetin GTase; UGTCs2; UGT75L6; UDP-glucose:crocetin glucosyltransferase; UDP-glucose:crocetin 8-O-D-glucosyltransferase | ||||||||
Systematic name: | UDP-α-D-glucose:crocetin 8-O-D-glucosyltransferase | ||||||||
Comments: | In the plants Crocus sativus and Gardenia jasminoides this enzyme esterifies a free carboxyl group of crocetin and some crocetin glycosyl esters. The enzyme from Gardenia can also form glucosyl esters with 4-coumarate, caffeate and ferulate [3]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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EC | 2.4.1.318 | ||||||||
Accepted name: | demethyllactenocin mycarosyltransferase | ||||||||
Reaction: | dTDP-β-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin | ||||||||
For diagram of tylosin biosynthesis, click here | |||||||||
Glossary: | dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose demethyllactenocin = [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside |
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Other name(s): | tylCV (gene name); tylC5 (gene name) | ||||||||
Systematic name: | dTDP-β-L-mycarose:demethyllactenocin 4′-O-α-L-mycarosyltransferase | ||||||||
Comments: | The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
References: |
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EC | 2.4.1.330 | ||||||||
Accepted name: | β-D-glucosyl crocetin β-1,6-glucosyltransferase | ||||||||
Reaction: | (1) UDP-α-D-glucose + β-D-glucosyl crocetin = UDP + β-D-gentiobiosyl crocetin (2) UDP-α-D-glucose + bis(β-D-glucosyl) crocetin = UDP + β-D-gentiobiosyl β-D-glucosyl crocetin (3) UDP-α-D-glucose + β-D-gentiobiosyl β-D-glucosyl crocetin = UDP + crocin |
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For diagram of crocin biosynthesis, click here | |||||||||
Glossary: | crocin = bis(β-D-gentiobiosyl) crocetin crocetin = (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate |
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Other name(s): | UGT94E5; UDP-glucose:crocetin glucosyl ester glucosyltransferasee | ||||||||
Systematic name: | UDP-α-D-glucose:β-D-glucosyl crocetin β-1,6-glucosyltransferase | ||||||||
Comments: | The enzyme, characterized from the plant Gardenia jasminoides, adds a glucose to several crocetin glycosyl esters, but not to crocetin (cf. EC 2.4.1.271, crocetin glucosyltransferase). | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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