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1.1.1.320

Accepted name:

benzil reductase [(S)-benzoin forming]

Reaction:

(S)-benzoin + NADP⁺ = benzil + NADPH + H⁺

Glossary:

(S)-benzoin = (2S)-2-hydroxy-1,2-diphenylethanone
benzil = 1,2-diphenylethane-1,2-dione

Other name(s):

YueD

Systematic name:

(S)-benzoin:NADP⁺ oxidoreductase

Comments:

The enzyme also reduces 1-phenylpropane-1,2-dione. The enzyme from Bacillus cereus in addition reduces 1,4-naphthoquinone and 1-(4-methylphenyl)-2-phenylethane-1,2-dione with high efficiency [2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Maruyama, R., Nishizawa, M., Itoi, Y., Ito, S. and Inoue, M. Isolation and expression of a Bacillus cereus gene encoding benzil reductase. Biotechnol. Bioeng. 75 (2001) 630–633. [PMID: 11745140]
2.	Maruyama, R., Nishizawa, M., Itoi, Y., Ito, S. and Inoue, M. The enzymes with benzil reductase activity conserved from bacteria to mammals. J. Biotechnol. 94 (2002) 157–169. [DOI] [PMID: 11796169]

[EC 1.1.1.320 created 2012]

1.1.1.321

Accepted name:

benzil reductase [(R)-benzoin forming]

Reaction:

(R)-benzoin + NADP⁺ = benzil + NADPH + H⁺

Glossary:

(R)-benzoin = (2R)-2-hydroxy-1,2-diphenylethanone
benzil = 1,2-diphenylethane-1,2-dione

Systematic name:

(R)-benzoin:NADP⁺ oxidoreductase

Comments:

The enzyme from the bacterium Xanthomonas oryzae is able to reduce enantioselectively only one of the two carbonyl groups of benzil to give optically active (R)-benzoin.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Konishi, J., Ohta, H. and Tuchihashi, G. Asymmetric reduction of benzil to benzoin catalyzed by the enzyme system of a microorganism. Chem. Lett. 14 (1985) 1111–1112.

[EC 1.1.1.321 created 2012]

4.1.2.38

Accepted name:

benzoin aldolase

Reaction:

2-hydroxy-1,2-diphenylethanone = 2 benzaldehyde

Glossary:

thiamine diphosphate = 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-diphosphoethyl)-4-methyl-1,3-thiazolium
benzoin = 2-hydroxy-1,2-diphenylethanone

Other name(s):

benzaldehyde lyase; 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase

Systematic name:

2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)

Comments:

A thiamine-diphosphate protein.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 122097-01-2

References:

1.	González, B. and Vicuñna, R. Benzaldehyde lyase, a novel thiamine PPi-requiring enzyme, from Pseudomonas fluorescens biovar I. J. Bacteriol. 171 (1989) 2401–2405. [DOI] [PMID: 2496105]

[EC 4.1.2.38 created 1992]